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Study · Animal study (in vivo) · rat · 2011

3 results

[The effect of semax and its C-end peptide PGP on expression of the neurotrophins and their receptors in the rat brain during incomplete global ischemia].

Stavchanskiĭ VV, Tvorogova TV, Botsina AIu, Skvortsova VI, Limborskaia SA, Miasoedov NF, Dergunova LV

Molekuliarnaia biologiia1 Nov 2011Cited by 2 (Europe PMC)

PMID22295573 (opens in a new tab)PepBankPUB-22295573
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after bilateral carotid occlusion, semax treatment decreased the mRNA level of neurotrophin receptors in the frontal cortex, while PGP increased it.

    In plain wordsIn rats with reduced brain blood flow, semax lowered the mRNA of neurotrophin receptors in the frontal cortex, while PGP raised it.

    Peptide
    Semax
    Outcome
    DecreaseNeurotrophin receptor mRNA in the frontal cortex
    Study

    ratn: not reported in source

    Incomplete global ischemia (bilateral common carotid artery occlusion)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the frontal cortex, Semax treatment resulted in a decrease of mRNA level of receptors, while PGP treatment increased the level of these mRNA.
    1 context sentence
    Summary · context
    We have analyzed the effect of synthetic peptide semax and its C-terminal Pro-Gly-Pro tripeptide upon mRNAs expression of neurotrophins Ngf, Bdrf, Nt-3 and their receptors TrkA, TrkB, TrkC, p75 in rat frontal lobes, hippocampus and cerebellum after bilateral common carotid artery occlusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after bilateral carotid occlusion, semax overcame the occlusion-induced decrease in gene expression of neurotrophins and their receptors.

    In plain wordsIn rats with reduced brain blood flow, semax reversed the drop in neurotrophin and receptor gene activity that the blockage caused.

    Peptide
    Semax
    Outcome
    IncreaseNeurotrophin and receptor gene expression decrease caused by occlusion
    Study

    ratn: not reported in source

    Incomplete global ischemia (bilateral common carotid artery occlusion)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A decrease of gene expression of neurotrophins and their receptors caused by the occlusion was overcome by Semax and PGP.
    1 context sentence
    Summary · context
    We have analyzed the effect of synthetic peptide semax and its C-terminal Pro-Gly-Pro tripeptide upon mRNAs expression of neurotrophins Ngf, Bdrf, Nt-3 and their receptors TrkA, TrkB, TrkC, p75 in rat frontal lobes, hippocampus and cerebellum after bilateral common carotid artery occlusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after bilateral carotid occlusion, the maximal neuroprotective effect of semax and PGP occurred in the hippocampus 12 h after occlusion.

    In plain wordsIn rats with reduced brain blood flow, semax had its largest protective effect in the hippocampus 12 hours after the blockage.

    Peptide
    Semax
    Outcome
    IncreaseNeuroprotective effect in the hippocampus at 12 h after occlusion
    Study

    ratn: not reported in source

    Incomplete global ischemia (bilateral common carotid artery occlusion)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Maximal neuroprotective effect of both peptides has been observed in the hippocampus 12 h after occlusion.
    1 context sentence
    Summary · context
    We have analyzed the effect of synthetic peptide semax and its C-terminal Pro-Gly-Pro tripeptide upon mRNAs expression of neurotrophins Ngf, Bdrf, Nt-3 and their receptors TrkA, TrkB, TrkC, p75 in rat frontal lobes, hippocampus and cerebellum after bilateral common carotid artery occlusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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