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Study · Non-randomized trial · n = 12 · 2013

2 results

Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans.

Hansen M, Boesen A, Holm L, Flyvbjerg A, Langberg H, Kjaer M

Scandinavian journal of medicine & science in sports31 Jan 2012Cited by 96 (Europe PMC)

PMID22288768 (opens in a new tab)DOI10.1111/j.1600-0838.2011.01431.x (opens in a new tab)PepBankPUB-22288768
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, local IGF-I increased tendon collagen fractional synthesis rate compared with the saline-injected control leg.

    In plain wordsIn healthy men, tendon collagen production was higher in the IGF-I leg than in the saline-injected control leg.

    Peptide
    IGF-1 (mecasermin)
    Outcome
    IncreaseTendon collagen fractional synthesis rate
    Study

    n = 12

    Comparator
    Saline-injected control leg
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Two injections of 0.1 mL Increlex©, 24-h apart · Into patellar tendonAs given in this study (human).

    Measurements

    P value for tendon collagen fractional synthesis rate
    < 0.05 p value
    IGF-I leg versus saline control leg

    Source sentences

    Summary
    Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P < 0.05).
    3 context sentences
    Summary · context
    Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection.
    Summary · context
    Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated.
    Summary · context
    Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, peritendinous PINP was higher in the IGF-I leg than in the saline-injected control leg.

    In plain wordsIn healthy men, the collagen production marker PINP was higher around the IGF-I tendon than around the saline-injected control tendon.

    Peptide
    IGF-1 (mecasermin)
    Outcome
    IncreasePeritendinous PINP
    Study

    n = 12

    Comparator
    Saline-injected control leg
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Two injections of 0.1 mL Increlex©, 24-h apart · Into patellar tendonAs given in this study (human).

    Measurements

    P value for peritendinous PINP
    < 0.05 p value
    IGF-I leg versus saline control leg

    Source sentences

    Summary
    Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P < 0.05).
    3 context sentences
    Summary · context
    Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique.
    Summary · context
    Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated.
    Summary · context
    Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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