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Study · Randomized controlled trial · n = 55 · 2012

2 results

Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: possible links to autism.

Sauer C, Montag C, Wörner C, Kirsch P, Reuter M

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology25 Jan 2012Cited by 73 (Europe PMC)

PMID22278094 (opens in a new tab)PMCIDPMC3327852 (opens in a new tab)DOI10.1038/npp.2011.333 (opens in a new tab)PepBankPUB-22278094
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy young men, intranasal oxytocin made differences between CD38 genotypes more evident, but the increase was not statistically significant.

    In plain wordsIn healthy young men, oxytocin nasal spray made differences between CD38 gene variants look larger, but the increase was not statistically significant.

    Peptide
    Oxytocin
    Outcome
    No significant changeGenotype differences in social processing under oxytocin
    Study

    n = 55

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Under OT activation differences between genotypes were more evident (though not statistically significantly increased
    1 context sentence
    Summary · context
    Using an imaging genetics approach, we studied differential effects of an intranasal OT application on neural processing of social stimuli in 55 healthy young men depending on their CD38 gene variant in a double-blind placebo-controlled crossover design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young men who were homozygous for the CD38 rs3796863 risk allele, reaction times during social processing were accelerated under intranasal oxytocin; the abstract gives no significance test for this result.

    In plain wordsIn young men with two CD38 risk alleles, reaction times in social tasks were faster under oxytocin nasal spray; no significance test was stated.

    Peptide
    Oxytocin
    Outcome
    DecreaseReaction time in homozygotic CD38 risk allele carriers
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    RT were accelerated in homozygotic risk allele carriers.
    1 context sentence
    Summary · context
    Using an imaging genetics approach, we studied differential effects of an intranasal OT application on neural processing of social stimuli in 55 healthy young men depending on their CD38 gene variant in a double-blind placebo-controlled crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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