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Study · Measured the body's own peptide · 2012

7 results

Maternal contact differentially modulates central and peripheral oxytocin in rat pups during a brief regime of mother-pup interaction that induces a filial huddling preference.

Kojima S, Stewart RA, Demas GE, Alberts JR

Journal of neuroendocrinology1 May 2012Cited by 66 (Europe PMC)

PMID22260655 (opens in a new tab)PMCIDPMC4060530 (opens in a new tab)DOI10.1111/j.1365-2826.2012.02280.x (opens in a new tab)PepBankPUB-22260655
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups, the body's own hypothalamic oxytocin increased during the 1-h separation from the home cage.

    In plain wordsIn rat pups, natural oxytocin in the hypothalamus rose during a 1-hour separation.

    Peptide
    Oxytocin
    Outcome
    IncreaseHypothalamic oxytocin during separation
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Before separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Both hypothalamic and serum oxytocin increased during the 1-h separation.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups, the body's own serum oxytocin increased during the 1-h separation from the home cage.

    In plain wordsIn rat pups, natural oxytocin in the blood rose during a 1-hour separation.

    Peptide
    Oxytocin
    Outcome
    IncreaseSerum oxytocin during separation
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Before separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Both hypothalamic and serum oxytocin increased during the 1-h separation.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups placed with a foster mother after separation, the body's own hypothalamic oxytocin stayed at the same concentration through the fostering period.

    In plain wordsIn rat pups placed with a foster mother, natural oxytocin in the hypothalamus stayed at the same level.

    Peptide
    Oxytocin
    Outcome
    No significant changeHypothalamic oxytocin with a foster mother
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Level after separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Pups placed with a foster mother after the separation maintained the same concentrations in the hypothalamus and serum through the fostering period.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups placed with a foster mother after separation, the body's own serum oxytocin stayed at the same concentration through the fostering period.

    In plain wordsIn rat pups placed with a foster mother, natural oxytocin in the blood stayed at the same level.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin with a foster mother
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Level after separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Pups placed with a foster mother after the separation maintained the same concentrations in the hypothalamus and serum through the fostering period.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups placed with no mother, the body's own hypothalamic oxytocin increased further.

    In plain wordsIn rat pups left without a mother, natural oxytocin in the hypothalamus rose further.

    Peptide
    Oxytocin
    Outcome
    IncreaseHypothalamic oxytocin without a mother
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Level after separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    By contrast, pups placed with no mother showed a further increase in hypothalamic oxytocin but serum oxytocin decreased.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups placed with no mother, the body's own serum oxytocin decreased.

    In plain wordsIn rat pups left without a mother, natural oxytocin in the blood fell.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin without a mother
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Level after separation
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    By contrast, pups placed with no mother showed a further increase in hypothalamic oxytocin but serum oxytocin decreased.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07AnimalEndogenous levelAnimal study (in vivo)Other

    In rat pups, skin-to-skin contact with the mother, but not simple physical contact or licking/grooming, was positively correlated with the body's own hypothalamic oxytocin.

    In plain wordsIn rat pups, skin-to-skin contact with the mother was linked to higher natural oxytocin in the hypothalamus; other contact types were not.

    Peptide
    Oxytocin
    Outcome
    IncreaseHypothalamic oxytocin and skin-to-skin contact
    Study

    ratn: not reported in source

    14-day-old rat pups separated from the home cage, with or without a foster mother
    Comparator
    Simple physical contact or licking/grooming
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Behavioural analyses revealed that skin-to-skin contact with the mother, but not simple physical contact or maternal licking/grooming, was positively correlated with the pups' hypothalamic oxytocin concentrations.
    1 context sentence
    Summary · context
    Pairs of 14-day-old littermates were removed from their home cage for 1 h and then placed with a lactating foster mother for 2 h, or they remained isolated at room temperature.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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