Skip to content

Study · In vitro (cells) · 2012

6 results

The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

Nijnik A, Pistolic J, Cho P, Filewod NC, Falsafi R, Ramin A, Harder KW, Hancock RE

Journal of leukocyte biology13 Jan 2012Cited by 3 (Europe PMC)

PMID22246800 (opens in a new tab)PMCIDPMC3409631 (opens in a new tab)DOI10.1189/jlb.0411191 (opens in a new tab)PepBankPUB-22246800
Source linkPubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In monocytic cells, LL‑37 induced phosphorylation of Src family kinases (SFKs).

    In plain wordsIn lab tests on immune cells, LL‑37 switched on a family of signalling enzymes called Src family kinases.

    Peptide
    LL-37
    Outcome
    IncreaseSFK phosphorylation induced by LL-37
    Study

    n: not reported in source

    monocytic cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LL-37 induced SFK phosphorylation
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

Studies that did not test the peptide alone5

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 02LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement

    In monocytic cells, chemical inhibitors of SFKs suppressed chemokine production in response to LL‑37 stimulation.

    In plain wordsIn lab tests on immune cells, blocking Src family kinases reduced the chemokine release that LL‑37 triggers.

    Peptide
    LL-37
    Outcome
    DecreaseChemokine production in response to LL-37 with SFK inhibitors
    Study

    n: not reported in source

    monocytic cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    chemical inhibitors of SFKs suppressed chemokine production in response to LL-37 stimulation.
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  2. 03LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    In monocytic cells, SFKs were required for the downstream activation of AKT in response to LL‑37.

    In plain wordsIn lab tests on immune cells, Src family kinases were needed for the AKT signal that follows LL‑37 treatment.

    Peptide
    LL-37
    Outcome
    Not applicableAKT activation downstream of LL-37 requires SFKs
    Study

    n: not reported in source

    monocytic cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    SFKs were required for the downstream activation of AKT
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  3. 04LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    In monocytic cells, Ca(2+) flux and MAPK induction were SFK-independent.

    In plain wordsIn lab tests on immune cells, calcium flux and MAPK signals after LL‑37 did not depend on Src family kinases.

    Peptide
    LL-37
    Outcome
    No significant changeCa(2+) flux and MAPK induction by LL-37 independent of SFKs
    Study

    n: not reported in source

    monocytic cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    but Ca(2+)-flux and MAPK induction were SFK-independent.
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  4. 05LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    Systematic siRNA knockdown of SFK members identified a requirement for Lyn in mediating LL‑37 activity in monocytic cells.

    In plain wordsIn lab tests on immune cells, silencing the Lyn enzyme showed that LL‑37 needs Lyn to act.

    Peptide
    LL-37
    Outcome
    Not applicableRequirement for Lyn in LL-37 activity (siRNA knockdown)
    Study

    n: not reported in source

    monocytic cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Through systematic siRNA knockdown of SFK members, a requirement for Lyn in mediating LL-37 activity was identified.
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  5. 06LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    Lyn-knockout mouse BMDMs further confirmed the involvement of Lyn in cathelicidin activities.

    In plain wordsIn cells from mice lacking Lyn, the Lyn enzyme was again shown to be involved in LL‑37 activity.

    Peptide
    LL-37
    Outcome
    Not applicableRequirement for Lyn in cathelicidin activity (Lyn-knockout BMDMs)
    Study

    mousen: not reported in source

    Lyn-knockout mouse bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    The involvement of Lyn in cathelicidin activities was further confirmed using Lyn-knockout mouse BMDMs.
    1 context sentence
    Summary · context
    Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.