Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro.

Yang X, Qian F, He HY, Liu KJ, Lan YZ, Ni B, Tian Y, Fu XL, Zhang J, Shen ZG, Li J, Yin Y, Li JT, Wu YZ

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas30 Nov 2011Cited by 21 (Europe PMC)

PMID22245858PMCIDPMC3854146DOI10.1590/s0100-879x2011007500159PepBankPUB-22245858

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In PBMCs from patients with gastric cancer, thymosin α1 at 50 µg/mL alone increased the percentage of CD4+CD25+Foxp3+ regulatory T cells.
In plain wordsIn lab tests on blood cells taken from gastric cancer patients, thymosin α1 raised the share of regulatory T cells.
Peptide
Thymosin alpha-1
Outcome
IncreasePercentage of CD4+CD25+Foxp3+ Tregs
Study
humann = 35
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
50 µg/mLAs given in this study (human).
Measurements
CD4+CD25+Foxp3+ cells before
1.68%
PBMCs from gastric cancer patients, untreated
CD4+CD25+Foxp3+ cells after
2.19%
PBMCs from gastric cancer patients, Tα1 50 µg/mL
Source sentences
Summary
The treatment of PBMCs from gastric cancer patients, with Tα1 (50 µg/mL) alone increased the percentage of CD4+CD25+Foxp3+ (suppressive antitumor-specific Tregs) from 1.68 ± 0.697 to 2.19 ± 0.795% (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of Tα1 on the frequency of CD4+ and CD8+ T cells, especially the CD4+CD25+Foxp3+ Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22).
Report a problemFND-2224585801
02LabIn vitro (cells)Efficacy outcome
In vitro, thymosin α1 increased IL-1β in PBMC cultures.
In plain wordsIn lab tests, thymosin α1 raised IL-1β production by blood immune cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-1β production
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Our results indicate that Tα1 increases the percentage of Tregs and IL-1β, TNF-α, and IL-6 in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of Tα1 on the frequency of CD4+ and CD8+ T cells, especially the CD4+CD25+Foxp3+ Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22).
Report a problemFND-2224585802
03LabIn vitro (cells)Efficacy outcome
In vitro, thymosin α1 increased TNF-α in PBMC cultures.
In plain wordsIn lab tests, thymosin α1 raised TNF-α production by blood immune cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseTNF-α production
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Our results indicate that Tα1 increases the percentage of Tregs and IL-1β, TNF-α, and IL-6 in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of Tα1 on the frequency of CD4+ and CD8+ T cells, especially the CD4+CD25+Foxp3+ Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22).
Report a problemFND-2224585803
04LabIn vitro (cells)Efficacy outcome
In vitro, thymosin α1 increased IL-6 in PBMC cultures.
In plain wordsIn lab tests, thymosin α1 raised IL-6 production by blood immune cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-6 production
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Our results indicate that Tα1 increases the percentage of Tregs and IL-1β, TNF-α, and IL-6 in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of Tα1 on the frequency of CD4+ and CD8+ T cells, especially the CD4+CD25+Foxp3+ Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22).
Report a problemFND-2224585804

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

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