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Study · Animal study (in vivo) · mouse · 2011

7 results

Study of anti-inflammatory effects of GB-115, a glycine-containing retropeptide cholecystokinin analog.

Shipaeva EV, Kovalenko LP, Sorokina AV, Kovalev GI, Tallerova AV, Kolik LG, Gudasheva TA, Durnev AD, Durnev AD, Seredenin SB

Bulletin of experimental biology and medicine1 Mar 2011Cited by 1 (Europe PMC)

PMID22235394 (opens in a new tab)DOI10.1007/s10517-011-1200-8 (opens in a new tab)PepBankPUB-22235394
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In experimental inflammation models, intraperitoneal GB‑115 showed anti-inflammatory effects.

    In plain wordsIn animal inflammation models, GB‑115 showed anti-inflammatory effects.

    Peptide
    GB-115
    Outcome
    DecreaseInflammation
    Study

    n: not reported in source

    ConA- and carrageenan-induced inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    0.1, 1, and 10 mg/kg · intraperitonealAs given in this study.

    Source sentences

    Summary
    Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, GB‑115 significantly alleviated pathological symptoms.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, GB‑115 reduced pathological symptoms.

    Peptide
    GB-115
    Outcome
    DecreasePathological symptoms
    Study

    mousen: not reported in source

    Female C57Bl/6 mice with experimental autoimmune encephalomyelitis
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltratio…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, GB‑115 improved spontaneous locomotor activity.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, GB‑115 improved spontaneous movement.

    Peptide
    GB-115
    Outcome
    IncreaseSpontaneous locomotor activity
    Study

    mousen: not reported in source

    Female C57Bl/6 mice with experimental autoimmune encephalomyelitis
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltratio…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, GB‑115 promoted recovery of thymus weight.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, GB‑115 promoted recovery of thymus weight.

    Peptide
    GB-115
    Outcome
    Direction not reportedThymus weight recovery
    Study

    mousen: not reported in source

    Female C57Bl/6 mice with experimental autoimmune encephalomyelitis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltratio…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, GB‑115 reduced brain perivascular edema.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, GB‑115 reduced swelling around brain blood vessels.

    Peptide
    GB-115
    Outcome
    DecreaseBrain perivascular edema
    Study

    mousen: not reported in source

    Female C57Bl/6 mice with experimental autoimmune encephalomyelitis
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltratio…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, GB‑115 reduced neutrophil infiltration of the brain perivascular space.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, GB‑115 reduced neutrophil entry around brain blood vessels.

    Peptide
    GB-115
    Outcome
    DecreaseBrain perivascular neutrophil infiltration
    Study

    mousen: not reported in source

    Female C57Bl/6 mice with experimental autoimmune encephalomyelitis
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltratio…
  7. 07AnimalAnimal study (in vivo)Mechanism

    In an unspecified animal model, intraperitoneal GB‑115 suppressed neutrophil active oxygen generation measured by chemiluminescence.

    In plain wordsIn an unspecified animal model, injected GB‑115 reduced neutrophil active oxygen generation measured by chemiluminescence.

    Peptide
    GB-115
    Outcome
    DecreaseNeutrophil active oxygen generation
    Study

    n: not reported in source

    Neutrophil chemiluminescence test after intraperitoneal injection
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 mg/kg · intraperitonealAs given in this study.

    Source sentences

    Summary
    Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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