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Study · Not a test of the peptide alone · 2012

4 results

Interaction between PEO-PPO-PEO copolymers and a hexapeptide in aqueous solutions.

Jia L, Guo C, Xiang J, Wang N, Yang L, Tang Y, Liu H

Langmuir : the ACS journal of surfaces and colloids9 Jan 2012Cited by 8 (Europe PMC)

PMID22185212 (opens in a new tab)DOI10.1021/la203693c (opens in a new tab)PepBankPUB-22185212
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In aqueous solution, copolymer PO methyl protons interacted with GHRP‑6 Ala, Trp and some Phe protons.

    In plain wordsIn lab tests, copolymer PO methyl protons contacted several parts of GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    Not applicableHydrophobic contacts
    Study

    n: not reported in source

    GHRP-6 and PEO-PPO-PEO copolymers in aqueous solution
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    (1)H NMR and nuclear Overhauser effect spectroscopy (NOESY) measurements determined that PO methyl protons interacted with methyl protons of the Ala moiety, aromatic protons of the Trp moiety, and some of the Phe aromatic protons.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In aqueous solution, the Lys moiety and part of the Phe moiety entered the hydrophilic EO environment through hydrogen bonding.

    In plain wordsIn lab tests, parts of GHRP‑6 entered the copolymer's water-attracting environment through hydrogen bonding.

    Peptide
    GHRP-6
    Outcome
    Not applicableHydrogen bonding
    Study

    n: not reported in source

    GHRP-6 and PEO-PPO-PEO copolymers in aqueous solution
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The Lys moiety and part of the Phe moiety entered the hydrophilic EO environment via hydrogen bonding.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In aqueous solution, GHRP‑6 and PEO-PPO-PEO copolymers formed a complex with 1:1 stoichiometry.

    In plain wordsIn lab tests, GHRP‑6 and copolymers formed a complex in a one-to-one ratio.

    Peptide
    GHRP-6
    Outcome
    Not applicableComplex stoichiometry
    Study

    n: not reported in source

    GHRP-6 and PEO-PPO-PEO copolymers in aqueous solution
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    PEO-PPO-PEO copolymers and the peptide formed a complex in 1:1 stoichiometry.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In aqueous solution, copolymers with more EO and PO units showed greater affinity for GHRP‑6.

    In plain wordsIn lab tests, copolymers with more EO and PO units bound GHRP‑6 more strongly.

    Peptide
    GHRP-6
    Outcome
    IncreaseCopolymer affinity
    Study

    n: not reported in source

    GHRP-6 and PEO-PPO-PEO copolymers in aqueous solution
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Binding constants between copolymers and GHRP-6 were determined, and it was indicated that the copolymers containing more EO and PO units will lead to greater affinity with the peptide.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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