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Study · Animal study (in vivo) · rat · 2012

2 results

Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y.

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O'Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR

International journal of obesity (2005)29 Nov 2011Cited by 13 (Europe PMC)

PMID22124449 (opens in a new tab)PMCIDPMC3378483 (opens in a new tab)DOI10.1038/ijo.2011.226 (opens in a new tab)PepBankPUB-22124449
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats that were undernourished after birth (PLP), submaximal doses of MTII reduced food intake more than in control rats.

    In plain wordsIn rats that were underfed as pups, small doses of melanotan II cut food intake more than in control rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake reduction by submaximal MTII in PLP rats
    Study

    ratn: not reported in source

    Comparator
    Control rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · third ventricleAs given in this study (rat).

    Source sentences

    Summary
    whereas submaximal doses of MTII reduced the food intake more in PLP rats.
    1 context sentence
    Summary · context
    Pups of normally nourished dams that are cross-fostered after birth to dams fed a low-protein (8% by weight) diet (postnatal low protein (PLP)) grow slower during the suckling period and remain small and lean throughout adulthood.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats that were undernourished after birth (PLP), maximal responses to MTII did not differ from control rats.

    In plain wordsIn rats that were underfed as pups, the strongest effect of melanotan II on eating was the same as in control rats.

    Peptide
    Melanotan II
    Outcome
    No significant changeMaximal food intake response to MTII in PLP rats
    Study

    ratn: not reported in source

    Comparator
    Control rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Submaximal doses of NPY increased the food intake less in PLP rats than in controls, whereas submaximal doses of MTII reduced the food intake more in PLP rats. Maximal responses did not differ between PLP and control rats.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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