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Study · Measured the body's own peptide · 2012

3 results

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes.

Juffer P, Jaspers RT, Lips P, Bakker AD, Klein-Nulend J

American journal of physiology. Endocrinology and metabolism22 Nov 2011Cited by 59 (Europe PMC)

PMID22114022 (opens in a new tab)DOI10.1152/ajpendo.00320.2011 (opens in a new tab)PepBankPUB-22114022
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    Unloaded MLO-Y4 osteocytes expressed MGF mRNA.

    In plain wordsIn cells, bone cells at rest made the body's own MGF messenger RNA.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMGF mRNA expression in unloaded osteocytes
    Study

    n: not reported in source

    MLO-Y4 osteocytes
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Unloaded MLO-Y4 osteocytes expressed mRNA of VEGF, HGF, IGF-I Ea, and MGF
    1 context sentence
    Summary · context
    Therefore, we investigated whether mechanical loading by pulsating fluid flow (PFF) modulates the mRNA and/or protein levels of muscle anabolic and metabolic factors in MLO-Y4 osteocytes.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In MLO-Y4 osteocytes, pulsating fluid flow at a peak shear stress rate of 44 Pa/s increased MGF mRNA 2.0-fold.

    In plain wordsIn cells, fluid flow on bone cells raised the body's own MGF messenger RNA about two times at the higher flow rate.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA after pulsating fluid flow at 44 Pa/s
    Study

    n: not reported in source

    MLO-Y4 osteocytes
    Comparator
    Unloaded cells
    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    MGF mRNA change
    2 fold
    PFF 44 Pa/s

    Source sentences

    Summary
    PFF increased mRNA levels of IGF-I Ea (2.1-fold) and MGF (2.0-fold)
    2 context sentences
    Summary · context
    at a peak shear stress rate of 44Pa/s
    Summary · context
    Therefore, we investigated whether mechanical loading by pulsating fluid flow (PFF) modulates the mRNA and/or protein levels of muscle anabolic and metabolic factors in MLO-Y4 osteocytes.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In MLO-Y4 osteocytes, pulsating fluid flow at 22 Pa/s did not increase MGF mRNA.

    In plain wordsIn cells, the lower flow rate did not raise the body's own MGF messenger RNA in bone cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA after pulsating fluid flow at 22 Pa/s
    Study

    n: not reported in source

    MLO-Y4 osteocytes
    Comparator
    Unloaded cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    PFF increased mRNA levels of IGF-I Ea (2.1-fold) and MGF (2.0-fold) at a peak shear stress rate of 44Pa/s, but not at 22Pa/s.
    1 context sentence
    Summary · context
    Therefore, we investigated whether mechanical loading by pulsating fluid flow (PFF) modulates the mRNA and/or protein levels of muscle anabolic and metabolic factors in MLO-Y4 osteocytes.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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