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Study · Animal study (in vivo) · rat · 2011

7 results

Superior neuroprotective effects of cerebrolysin in heat stroke following chronic intoxication of Cu or Ag engineered nanoparticles. A comparative study with other neuroprotective agents using biochemical and morphological approaches in the rat.

Sharma HS, Muresanu DF, Patnaik R, Stan AD, Vacaras V, Perju-Dumbrav L, Alexandru B, Buzoianu A, Opincariu I, Menon PK, Sharma A

Journal of nanoscience and nanotechnology1 Sept 2011Cited by 31 (Europe PMC)

PMID22097459 (opens in a new tab)DOI10.1166/jnn.2011.5114 (opens in a new tab)PepBankPUB-22097459
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats exposed to heat stress, cerebrolysin reduced behavioral stress symptoms.

    In plain wordsIn rats exposed to heat stress, cerebrolysin reduced behavioral stress symptoms.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBehavioral stress symptoms
    Study

    ratn: not reported in source

    Heat-stressed normal rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intravenous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with cerebrolysin (2.5 ml/kg, i.v.) daily for 3 days in normal rats before heat stress significantly reduced the behavioral stress symptoms and the breakdown of the BBB function, edema formation and neuronal injuries.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats exposed to heat stress, cerebrolysin reduced BBB breakdown.

    In plain wordsIn rats exposed to heat stress, cerebrolysin reduced blood-brain barrier breakdown.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBBB breakdown
    Study

    ratn: not reported in source

    Heat-stressed normal rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intravenous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with cerebrolysin (2.5 ml/kg, i.v.) daily for 3 days in normal rats before heat stress significantly reduced the behavioral stress symptoms and the breakdown of the BBB function, edema formation and neuronal injuries.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats exposed to heat stress, cerebrolysin reduced edema formation.

    In plain wordsIn rats exposed to heat stress, cerebrolysin reduced brain swelling.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema
    Study

    ratn: not reported in source

    Heat-stressed normal rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intravenous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with cerebrolysin (2.5 ml/kg, i.v.) daily for 3 days in normal rats before heat stress significantly reduced the behavioral stress symptoms and the breakdown of the BBB function, edema formation and neuronal injuries.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats exposed to heat stress, cerebrolysin reduced neuronal injuries.

    In plain wordsIn rats exposed to heat stress, cerebrolysin reduced nerve cell injuries.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNeuronal injuries
    Study

    ratn: not reported in source

    Heat-stressed normal rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intravenous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with cerebrolysin (2.5 ml/kg, i.v.) daily for 3 days in normal rats before heat stress significantly reduced the behavioral stress symptoms and the breakdown of the BBB function, edema formation and neuronal injuries.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In normal heat-stressed rats, cerebrolysin produced stronger neuroprotection than the other tested drugs.

    In plain wordsIn rats exposed to heat stress, cerebrolysin protected the brain more than the other tested drugs.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection versus other drugs
    Study

    ratn: not reported in source

    Heat-stressed normal rats
    Comparator
    Other neuroprotective drugs
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intravenous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    However, the magnitude and intensity of these neuroprotective effects were much less intense in all other drug treated rats after similar heat stress.
    2 context sentences
    Summary · context
    Pretreatment with cerebrolysin (2.5 ml/kg, i.v.) daily for 3 days in normal rats before heat stress significantly reduced the behavioral stress symptoms and the breakdown of the BBB function, edema formation and neuronal injuries.
    Summary · context
    For this purpose, the therapeutic efficacy of Cerebrolysin (2.5 or 5 ml/kg) recommended for stroke treatment was used in comparison with other drugs in standard doses recommended for such therapy in clinical situations e.g., levetiracetam (44 mg/kg), pregabalin (200 mg/kg), topiramate (40 mg/kg,i.p.…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nanoparticle-treated rats, cerebrolysin required almost double the dose to achieve comparable neuroprotection after heat stress.

    In plain wordsIn nanoparticle-treated rats, cerebrolysin required almost double the dose for comparable brain protection after heat stress.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection in nanoparticle-treated rats
    Study

    ratn: not reported in source

    Cu or Ag nanoparticle-treated heat-stressed rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kgAs given in this study (rat).

    Source sentences

    Summary
    On the other hand, almost double dose of cerebrolysin (5 ml/kg) was needed to achieve comparable neuroprotection in nanoparticles treated animals after heat stress.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In nanoparticle-treated heat-exposed rats, cerebrolysin provided greater neuroprotection than double doses of the other compounds.

    In plain wordsIn nanoparticle-treated rats exposed to heat, cerebrolysin protected the brain more than double doses of the other drugs.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection versus doubled doses of other drugs
    Study

    ratn: not reported in source

    Cu or Ag nanoparticle-treated heat-stressed rats
    Comparator
    Double doses of other compounds
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kgAs given in this study (rat).

    Source sentences

    Summary
    Whereas, double dose of all other compounds was much less effective in inducing neuroprotection in nanoparticles treated heat-exposed animals.
    1 context sentence
    Summary · context
    On the other hand, almost double dose of cerebrolysin (5 ml/kg) was needed to achieve comparable neuroprotection in nanoparticles treated animals after heat stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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