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Study · Not a test of the peptide alone · 2011

2 results

[Proteolysis of semax analogues with different N-terminal amino acids by aminopeptidases].

Shevchenko KV, V'iunova TV, Nagaev IIu, Andreeva LA, Alfeeva LIu, Miasoedov NF

Bioorganicheskaia khimiia1 Jul 2011Cited by 3 (Europe PMC)

PMID22096989 (opens in a new tab)DOI10.1134/s1068162011040133 (opens in a new tab)PepBankPUB-22096989
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 01LabNot a test of Semax aloneIn vitro (cell-free)Pharmacokinetics

    In an aminopeptidase assay, semax was less stable to proteolysis than its [Ala1], [Gly1] and [Thr1] analogues.

    In plain wordsIn lab tests, semax broke down faster than three modified versions of semax.

    Peptide
    Semax
    Outcome
    Not applicableProteolytic stability of semax versus its analogues
    Study

    n: not reported in source

    N-aminopeptidase proteolysis assay
    Comparator
    [Ala1]Sem, [Gly1]Sem and [Thr1]Sem
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    [Ala1]Sem, [Gly1]Sem and [Thr1]Sem semax analogues proved to be more stable to proteolysis than semax (Sem)
    1 context sentence
    Summary · context
    Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues ([Ala1]Sem, [Gly1]Sem, [Thr1]Sem, [Trp1]Sem) that are differ from semax in substitution of N-terminal Met residue were studied.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 02LabNot a test of Semax aloneIn vitro (cell-free)Mechanism

    In an aminopeptidase assay, all investigated semax analogues could be used as inhibitors of semax proteolysis.

    In plain wordsIn lab tests, all studied modified versions of semax could slow the breakdown of semax.

    Peptide
    Semax
    Outcome
    DecreaseAnalogues as inhibitors of semax proteolysis
    Study

    n: not reported in source

    N-aminopeptidase proteolysis assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    It is found that all investigated analogues can be used as inhibitors in Sem proteolysis.
    1 context sentence
    Summary · context
    Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues ([Ala1]Sem, [Gly1]Sem, [Thr1]Sem, [Trp1]Sem) that are differ from semax in substitution of N-terminal Met residue were studied.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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