Skip to content

Study · Animal study (in vivo) · rat · 2012

3 results

Dizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress.

Umriukhin PE, Koplik EV, Sudakov KV

Neuroscience letters6 Nov 2011Cited by 3 (Europe PMC)

PMID22094385 (opens in a new tab)DOI10.1016/j.neulet.2011.11.001 (opens in a new tab)PepBankPUB-22094385
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male Wistar rats, intraperitoneal DSIP (60 nmol/kg) decreased the number of Fos-immunoreactive cells in the paraventricular nucleus activated by immobilization.

    In plain wordsIn rats, DSIP reduced the number of stress-activated Fos-positive cells in a brain area that controls the stress response.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseFos-immunoreactive cells in the paraventricular nucleus (parvocellular part)
    Study

    ratn: not reported in source

    Male Wistar rats, immobilization stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 nmol/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    intraperitoneal (i.p.) DSIP injection (60 nmol/kg) decreased the number of Fos-immunoreactive (Fos-IR) cells in the pPVN, activated by immobilization.
    1 context sentence
    Summary · context
    were studied in the parvocellular subdivision of the hypothalamic paraventricular nucleus (pPVN) of male Wistar rats with either high or low resistance to emotional stress, predicted from differences in their open-field behaviour.

Studies that did not test the peptide alone2

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats predisposed to emotional stress, the NMDA-receptor antagonist dizocilpine prevented the DSIP-induced inhibition of c-Fos expression in the paraventricular nucleus.

    In plain wordsIn rats prone to stress, a drug that blocks NMDA receptors stopped DSIP from lowering c-Fos in a stress-related brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDizocilpine (MK-801) block of DSIP inhibition of c-Fos in stress-predisposed rats
    Study

    ratn: not reported in source

    Male Wistar rats, immobilization stress
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The NMDA-receptor antagonist dizocilpine (MK-801) (90 nmol i.c.v.) prevented the inhibition of c-Fos expression by DSIP in the pPVN of rats predisposed to emotional stress.
    1 context sentence
    Summary · context
    were studied in the parvocellular subdivision of the hypothalamic paraventricular nucleus (pPVN) of male Wistar rats with either high or low resistance to emotional stress, predicted from differences in their open-field behaviour.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats resistant to emotional stress, the protein synthesis inhibitor cycloheximide prevented the DSIP-induced inhibition of c-Fos expression in the paraventricular nucleus.

    In plain wordsIn stress-resistant rats, a drug that blocks protein synthesis stopped DSIP from lowering c-Fos in a stress-related brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCycloheximide block of DSIP inhibition of c-Fos in stress-resistant rats
    Study

    ratn: not reported in source

    Male Wistar rats, immobilization stress
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The protein synthesis inhibitor cycloheximide (210 nmol i.c.v.) prevented the inhibition of c-Fos expression by DSIP in the pPVN of rats that were resistant to emotional stress.
    1 context sentence
    Summary · context
    were studied in the parvocellular subdivision of the hypothalamic paraventricular nucleus (pPVN) of male Wistar rats with either high or low resistance to emotional stress, predicted from differences in their open-field behaviour.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.