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Study · Measured the body's own peptide · 2011

2 results

Adrenergic stimulation decreases osteoblast oxytocin synthesis.

Cuscito C, Colaianni G, Tamma R, Greco G, Dell'Endice S, Yuen T, Sun L, Zaidi M, Di Benedetto A, Zallone A

Annals of the New York Academy of Sciences1 Nov 2011Cited by 5 (Europe PMC)

PMID22082365 (opens in a new tab)DOI10.1111/j.1749-6632.2011.06235.x (opens in a new tab)PepBankPUB-22082365
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In murine osteoblasts and MC3T3-E1 cells, alpha-1 and beta-2 adrenergic agonists downregulated synthesis of the body's own oxytocin.

    In plain wordsIn cells, drugs that mimic adrenaline signals lowered the body's own oxytocin production in bone-forming cells.

    Peptide
    Oxytocin
    Outcome
    DecreaseOsteoblast oxytocin synthesis after adrenergic agonists
    Study

    mousen: not reported in source

    Primary murine osteoblasts and MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    We then showed that α(1) and β(2) adrenergic agonists downregulated OT synthesis
    1 context sentence
    Summary · context
    We first confirmed that α(1b) and β(2) adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3-E1 cells.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In murine osteoblasts and MC3T3-E1 cells, each adrenergic antagonist reversed the agonist-induced decrease in the body's own oxytocin synthesis.

    In plain wordsIn cells, blocking the adrenaline receptors reversed the drop in the body's own oxytocin production.

    Peptide
    Oxytocin
    Outcome
    IncreaseReversal of agonist effect on oxytocin synthesis by antagonists
    Study

    mousen: not reported in source

    Primary murine osteoblasts and MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    and that the effect of each agonist was reversed by its respective antagonist.
    1 context sentence
    Summary · context
    We first confirmed that α(1b) and β(2) adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3-E1 cells.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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