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Study · Animal study (in vivo) · old world monkeys · 2011

5 results

A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.

Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA and 5 more

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Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R

Science translational medicine1 Nov 2011Cited by 77 (Europe PMC)

PMID22072637 (opens in a new tab)PMCIDPMC3666164 (opens in a new tab)DOI10.1126/scitranslmed.3002621 (opens in a new tab)PepBankPUB-22072637
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In obese monkeys, adipotide induced targeted apoptosis in white adipose blood vessels.

    In plain wordsIn monkeys, adipotide induced cell death in white fat blood vessels.

    Peptide
    Adipotide
    Outcome
    IncreaseWhite adipose vascular apoptosis
    Study

    Old World monkeysn: not reported in source

    obese monkeys
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss and improved insulin resistance in obese monkeys.
    1 context sentence
    Summary · context
    Here, we evaluate the ligand-directed peptidomimetic CKGGRAKDC-GG-(D)(KLAKLAK)(2) (henceforth termed adipotide) in obese Old World monkeys.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese monkeys, adipotide produced rapid weight loss.

    In plain wordsIn monkeys, adipotide reduced body weight.

    Peptide
    Adipotide
    Outcome
    DecreaseBody weight
    Study

    Old World monkeysn: not reported in source

    obese monkeys
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss and improved insulin resistance in obese monkeys.
    1 context sentence
    Summary · context
    Here, we evaluate the ligand-directed peptidomimetic CKGGRAKDC-GG-(D)(KLAKLAK)(2) (henceforth termed adipotide) in obese Old World monkeys.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In obese monkeys, adipotide improved insulin resistance.

    In plain wordsIn monkeys, adipotide improved insulin resistance.

    Peptide
    Adipotide
    Outcome
    DecreaseInsulin resistance
    Study

    Old World monkeysn: not reported in source

    obese monkeys
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss and improved insulin resistance in obese monkeys.
    1 context sentence
    Summary · context
    Here, we evaluate the ligand-directed peptidomimetic CKGGRAKDC-GG-(D)(KLAKLAK)(2) (henceforth termed adipotide) in obese Old World monkeys.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In obese monkeys, imaging confirmed a marked reduction in white adipose tissue after adipotide treatment.

    In plain wordsIn monkeys, imaging showed less white fat after adipotide treatment.

    Peptide
    Adipotide
    Outcome
    DecreaseWhite adipose tissue
    Study

    Old World monkeysn: not reported in source

    obese monkeys
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Magnetic resonance imaging and dual-energy x-ray absorptiometry confirmed a marked reduction in white adipose tissue.
    1 context sentence
    Summary · context
    Here, we evaluate the ligand-directed peptidomimetic CKGGRAKDC-GG-(D)(KLAKLAK)(2) (henceforth termed adipotide) in obese Old World monkeys.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In monkeys from three species, adipotide produced predictable and reversible changes in renal proximal tubule function.

    In plain wordsIn monkeys, adipotide changed kidney tubule function, and the changes were reversible.

    Peptide
    Adipotide
    Outcome
    Direction not reportedRenal proximal tubule function
    Study

    Old World monkeysn: not reported in source

    obese monkeys
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At experimentally determined optimal doses, monkeys from three different species displayed predictable and reversible changes in renal proximal tubule function.
    1 context sentence
    Summary · context
    Here, we evaluate the ligand-directed peptidomimetic CKGGRAKDC-GG-(D)(KLAKLAK)(2) (henceforth termed adipotide) in obese Old World monkeys.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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