The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells.

In human periodontal ligament cells, LL‑37 at 0.1 and 1 µM totally reversed lipopolysaccharide-induced MCP-1 expression.

In plain wordsIn cells, LL‑37 completely reversed the rise in the inflammatory signal MCP-1 caused by bacterial LPS.

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In human periodontal ligament cells, LL‑37 at 0.1 and 1 µM suppressed lipopolysaccharide-induced IL-6 expression by 50-70%.

In plain wordsIn cells, LL‑37 reduced the rise in the inflammatory signal IL-6 caused by bacterial LPS by about half or more.

Measurements

IL-6 expression suppression

50 to 70%

LL-37 0.1 and 1 µM

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In human periodontal ligament cells, LL‑37 had no effect on alkaline phosphatase activity, a marker of cell differentiation.

In plain wordsIn cells, LL‑37 did not change alkaline phosphatase activity, a marker of cell maturation.

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In human periodontal ligament cells, LL‑37 at 8 µM strongly reduced cell number.

In plain wordsIn cells, a high dose of LL‑37 strongly reduced the number of cells.

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In human periodontal ligament cells, LL‑37 at 8 µM attenuated DNA synthesis by about 90%, an antiproliferative effect.

In plain wordsIn cells, a high dose of LL‑37 cut DNA synthesis by about 90%, which slows cell growth.

Measurements

DNA synthesis reduction

≈ 90%

LL-37 8 µM

Source sentences

In human periodontal ligament cells, LL‑37 at 8 µM altered cell morphology in an apoptosis-like fashion.

In plain wordsIn cells, a high dose of LL‑37 changed cell shape in a way that looks like cell death.

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In human periodontal ligament cells, LL‑37 at 1 and 8 µM increased the quantity of activated caspase 3, suggesting apoptosis.

In plain wordsIn cells, LL‑37 raised a marker of cell death, activated caspase 3.

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