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Study · Animal study (in vivo) · rat · 2011

5 results

The erythropoietin-derived peptide mimetic pHBSP affects cellular and cognitive consequences in a rat post-status epilepticus model.

Seeger N, Zellinger C, Rode A, Roloff F, Bicker G, Russmann V, Fischborn S, Wendt H, Potschka H

Epilepsia2 Nov 2011Cited by 19 (Europe PMC)

PMID22050420 (opens in a new tab)DOI10.1111/j.1528-1167.2011.03302.x (opens in a new tab)PepBankPUB-22050420
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats after status epilepticus, pHBSP further enhanced the status epilepticus-associated increase in hippocampal cell proliferation.

    In plain wordsIn rats after prolonged seizures, pHBSP further increased new cell growth in the hippocampus.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseHippocampal cell proliferation after status epilepticus
    Study

    Ratn: not reported in source

    Post-status epilepticus model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both pHBSP and erythropoietin further enhanced the status epilepticus-associated increase in hippocampal cell proliferation.
    1 context sentence
    Summary · context
    In a post-status epilepticus model in rats, we determined the effects of pHBSP and of recombinant human erythropoietin with short-term administration following status epilepticus.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats after status epilepticus, pHBSP seemed to promote neuronal differentiation and survival, resulting in a significant increase in neurogenesis.

    In plain wordsIn rats after prolonged seizures, pHBSP appeared to increase the formation of new nerve cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseNeurogenesis after status epilepticus
    Study

    Ratn: not reported in source

    Post-status epilepticus model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thereby, pHBSP seemed to promote neuronal differentiation and survival resulting in a significant increase in neurogenesis.
    1 context sentence
    Summary · context
    In a post-status epilepticus model in rats, we determined the effects of pHBSP and of recombinant human erythropoietin with short-term administration following status epilepticus.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after status epilepticus, pHBSP did not affect the number of animals with spontaneous recurrent seizures.

    In plain wordsIn rats after prolonged seizures, pHBSP did not change how many animals had repeated seizures.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeAnimals with spontaneous recurrent seizures
    Study

    Ratn: not reported in source

    Post-status epilepticus model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither pHBSP nor erythropoietin affected the number of animals exhibiting spontaneous recurrent seizures as well as the seizure frequency in the chronic phase.
    1 context sentence
    Summary · context
    In a post-status epilepticus model in rats, we determined the effects of pHBSP and of recombinant human erythropoietin with short-term administration following status epilepticus.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after status epilepticus, pHBSP did not affect seizure frequency in the chronic phase.

    In plain wordsIn rats after prolonged seizures, pHBSP did not change how often seizures happened later.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeSeizure frequency in the chronic phase
    Study

    Ratn: not reported in source

    Post-status epilepticus model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither pHBSP nor erythropoietin affected the number of animals exhibiting spontaneous recurrent seizures as well as the seizure frequency in the chronic phase.
    1 context sentence
    Summary · context
    In a post-status epilepticus model in rats, we determined the effects of pHBSP and of recombinant human erythropoietin with short-term administration following status epilepticus.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In epileptic rats, pHBSP attenuated cognitive deficits in the Morris water maze, but the deficits were not abolished and the effects were not observed consistently until the end of the study.

    In plain wordsIn rats with epilepsy, pHBSP reduced maze learning problems but did not remove them, and the effect was not consistent to the end.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseCognitive deficits in the Morris water maze
    Study

    Ratn: not reported in source

    Post-status epilepticus model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the Morris water maze, pHBSP attenuated cognitive deficits in epileptic animals.
    2 context sentences
    Summary · context
    However, it needs to be considered that learning deficits were not abolished by pHBSP and that the effects were not observed consistently until the end of the study.
    Summary · context
    In a post-status epilepticus model in rats, we determined the effects of pHBSP and of recombinant human erythropoietin with short-term administration following status epilepticus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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