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Study · Randomized controlled trial · n = 100 · 2012

15 results

Acute intranasal oxytocin improves positive self-perceptions of personality.

Cardoso C, Ellenbogen MA, Linnen AM

Psychopharmacology20 Oct 2011Cited by 68 (Europe PMC)

PMID22012170 (opens in a new tab)DOI10.1007/s00213-011-2527-6 (opens in a new tab)PepBankPUB-22012170
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased NEO-PI-R extraversion ratings versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated extraversion compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseNEO-PI-R extraversion
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal oxytocin increased ratings of NEO-PI-R extraversion and openness to experiences [F(1,98) = 4.910, p = .025
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased NEO-PI-R openness to experiences ratings versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated openness to experiences compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseNEO-PI-R openness to experiences
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal oxytocin increased ratings of NEO-PI-R extraversion and openness to experiences [F(1,98) = 4.910, p = .025, partial η (2) = .05; F(1,98) = 6.021, p = .016
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the positive emotions facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated positive emotions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePositive emotions facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.48 d
    positive emotions

    Source sentences

    Summary
    positive emotions (d = 0.48, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the warmth facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated warmth compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseWarmth facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.47 d
    warmth

    Source sentences

    Summary
    warmth (d = 0.47, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the openness to values facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated openness to values compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseOpenness to values facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.45 d
    openness to values

    Source sentences

    Summary
    openness to values (d = 0.45, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the openness to ideas facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated openness to ideas compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseOpenness to ideas facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.4 d
    openness to ideas

    Source sentences

    Summary
    ideas (d = 0.40, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the trust facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated trust compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseTrust facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.44 d
    trust

    Source sentences

    Summary
    trust (d = 0.44, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin increased the altruism facet versus placebo.

    In plain wordsIn university students, nasal oxytocin raised self-rated altruism compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAltruism facet
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen d
    0.4 d
    altruism

    Source sentences

    Summary
    altruism (d = 0.40, p < .05)
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on negative emotionality ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated negative emotionality.

    Peptide
    Oxytocin
    Outcome
    No significant changeNegative emotionality
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on conscientiousness ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated conscientiousness.

    Peptide
    Oxytocin
    Outcome
    No significant changeConscientiousness
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on rejection sensitivity ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated rejection sensitivity.

    Peptide
    Oxytocin
    Outcome
    No significant changeRejection sensitivity
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on depression ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated depression.

    Peptide
    Oxytocin
    Outcome
    No significant changeDepression ratings
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  13. 13HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on worry ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated worry.

    Peptide
    Oxytocin
    Outcome
    No significant changeWorry
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  14. 14HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on self-esteem ratings.

    In plain wordsIn university students, nasal oxytocin did not change self-rated self-esteem.

    Peptide
    Oxytocin
    Outcome
    No significant changeSelf-esteem
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.
  15. 15HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no influence on perceived social support ratings.

    In plain wordsIn university students, nasal oxytocin did not change perceived social support.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceived social support
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support.
    1 context sentence
    Summary · context
    In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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