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Study · Animal study (in vivo) · rat · 2012

7 results

Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats.

Morton GJ, Thatcher BS, Reidelberger RD, Ogimoto K, Wolden-Hanson T, Baskin DG, Schwartz MW, Blevins JE

American journal of physiology. Endocrinology and metabolism18 Oct 2011Cited by 176 (Europe PMC)

PMID22008455 (opens in a new tab)PMCIDPMC3328087 (opens in a new tab)DOI10.1152/ajpendo.00296.2011 (opens in a new tab)PepBankPUB-22008455
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats on a high-fat or low-fat diet, peripheral oxytocin reduced food intake dose-dependently, to a similar extent on either diet.

    In plain wordsIn obese rats, oxytocin given outside the brain lowered food intake as the dose went up, on either diet.

    Peptide
    Oxytocin
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    peripheral administration of oxytocin dose-dependently reduces food intake and body weight to a similar extent in rats maintained on either diet.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats on a high-fat or low-fat diet, peripheral oxytocin reduced body weight dose-dependently, to a similar extent on either diet.

    In plain wordsIn obese rats, oxytocin given outside the brain lowered body weight as the dose went up, on either diet.

    Peptide
    Oxytocin
    Outcome
    DecreaseBody weight
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    peripheral administration of oxytocin dose-dependently reduces food intake and body weight to a similar extent in rats maintained on either diet.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In leptin receptor-deficient Koletsky rats, the weight-loss effect of oxytocin remained intact relative to lean littermates.

    In plain wordsIn rats lacking the leptin receptor, oxytocin still caused weight loss, as in lean littermates.

    Peptide
    Oxytocin
    Outcome
    DecreaseWeight loss in leptin receptor-deficient Koletsky rats
    Study

    ratn: not reported in source

    Leptin receptor-deficient Koletsky (fa(k)/fa(k)) rats
    Comparator
    Lean littermates
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the effect of oxytocin to induce weight loss remained intact in leptin receptor-deficient Koletsky (fa(k)/fa(k)) rats relative to their lean littermates.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, systemic oxytocin caused a robust neuronal c-Fos response in the NTS and area postrema, which was larger in rats made obese on a high-fat diet than in lean controls.

    In plain wordsIn rats, oxytocin activated hindbrain neurons, and this response was stronger in rats made obese on a high-fat diet.

    Peptide
    Oxytocin
    Outcome
    Increasec-Fos induction in nucleus of the solitary tract and area postrema
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Comparator
    Lean low-fat-diet controls
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    We observed a robust neuronal response to oxytocin in these hindbrain areas that was unexpectedly increased in rats rendered obese on a HFD relative to lean, LFD-fed controls.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats, repeated daily peripheral oxytocin produced a sustained reduction of food intake.

    In plain wordsIn obese rats, daily oxytocin outside the brain kept food intake lower over time.

    Peptide
    Oxytocin
    Outcome
    DecreaseFood intake with repeated daily administration in DIO rats
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · peripheral · repeated dailyAs given in this study (rat).

    Source sentences

    Summary
    Finally, we report that repeated daily peripheral administration of oxytocin in DIO animals elicited a sustained reduction of food intake and body weight while preventing the reduction of energy expenditure characteristic of weight-reduced animals.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats, repeated daily peripheral oxytocin produced a sustained reduction of body weight.

    In plain wordsIn obese rats, daily oxytocin outside the brain kept body weight lower over time.

    Peptide
    Oxytocin
    Outcome
    DecreaseBody weight with repeated daily administration in DIO rats
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · peripheral · repeated dailyAs given in this study (rat).

    Source sentences

    Summary
    Finally, we report that repeated daily peripheral administration of oxytocin in DIO animals elicited a sustained reduction of food intake and body weight while preventing the reduction of energy expenditure characteristic of weight-reduced animals.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats, repeated daily peripheral oxytocin prevented the reduction of energy expenditure that is typical of weight-reduced animals.

    In plain wordsIn obese rats, daily oxytocin prevented the drop in energy use that usually follows weight loss.

    Peptide
    Oxytocin
    Outcome
    Not applicableEnergy expenditure with repeated daily administration in DIO rats
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · peripheral · repeated dailyAs given in this study (rat).

    Source sentences

    Summary
    Finally, we report that repeated daily peripheral administration of oxytocin in DIO animals elicited a sustained reduction of food intake and body weight while preventing the reduction of energy expenditure characteristic of weight-reduced animals.
    1 context sentence
    Summary · context
    To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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