Alcohol and aggressive behavior in men--moderating effects of oxytocin receptor gene (OXTR) polymorphisms.

Johansson A, Bergman H, Corander J, Waldman ID, Karrani N, Salo B, Jern P, Algars M, Sandnabba K, Santtila P, Westberg L

Genes, brain, and behavior17 Nov 2011Cited by 39 (Europe PMC)

PMID22008269DOI10.1111/j.1601-183x.2011.00744.xPepBankPUB-22008269

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01HumanNot a test of Oxytocin aloneRandomized controlled trialOther
In Finnish men, twelve oxytocin receptor gene polymorphisms had no main effects on aggressive behavior after controlling for multiple testing.
In plain wordsIn Finnish men, variants of the oxytocin receptor gene alone were not linked to aggressive behavior.
Peptide
Oxytocin
Outcome
No significant changeMain effects of OXTR polymorphisms on aggressive behavior
Study
n = 116
Outcome group
Social behavior and cognition · Mental health and mood
Source sentences
Summary
No main effects of the polymorphisms on aggressive behavior were found after controlling for multiple testing.
1 context sentence(design, population, supporting numbers)
Summary · context
Twelve OXTR polymorphisms were genotyped in 116 Finnish men [aged 18-30, M = 22.7, standard deviation (SD) = 2.4] who were randomly assigned to an alcohol condition in which they received an alcohol dose of 0.7 g pure ethanol/kg body weight or a placebo condition.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2200826901
02HumanNot a test of Oxytocin aloneRandomized controlled trialOther
In Finnish men, alcohol interacted with the OXTR variants rs4564970 and rs1488467 on aggressive behavior; only rs4564970 stayed significant after multiple-test control.
In plain wordsIn Finnish men, alcohol and some oxytocin receptor gene variants together were linked to aggression; one variant held up after strict testing.
Peptide
Oxytocin
Outcome
Not applicableInteraction of alcohol and OXTR polymorphisms (rs4564970, rs1488467) on aggressive behavior
Study
n = 116
Outcome group
Social behavior and cognition · Mental health and mood
Source sentences
Summary
The interactive effects between alcohol and two of the OXTR polymorphisms (rs4564970 and rs1488467) on aggressive behavior were nominally significant and remained significant for the rs4564970 when controlled for multiple tests.
1 context sentence(design, population, supporting numbers)
Summary · context
Twelve OXTR polymorphisms were genotyped in 116 Finnish men [aged 18-30, M = 22.7, standard deviation (SD) = 2.4] who were randomly assigned to an alcohol condition in which they received an alcohol dose of 0.7 g pure ethanol/kg body weight or a placebo condition.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2200826902

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Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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