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Study · Randomized controlled trial · n = 100 · 2012

3 results

Coping style moderates the effect of intranasal oxytocin on the mood response to interpersonal stress.

Cardoso C, Linnen AM, Joober R, Ellenbogen MA

Experimental and clinical psychopharmacology10 Oct 2011Cited by 39 (Europe PMC)

PMID21988218 (opens in a new tab)DOI10.1037/a0025763 (opens in a new tab)PepBankPUB-21988218
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy students, the effect of intranasal oxytocin on stress-related anxiety showed a significant drug by emotion-oriented coping by sex interaction.

    In plain wordsIn healthy students, whether nasal oxytocin changed anxiety under stress depended on coping style and sex.

    Peptide
    Oxytocin
    Outcome
    Not applicableStress-related change in anxiety, moderated by emotion-oriented coping and sex
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Multiple regression analyses predicting stress-related changes in anxiety revealed a significant Drug × Emotion-oriented coping × Sex interaction [pr2 = .06, b = 6.074, t(91) = -2.526, p = .014].
    2 context sentences
    Summary · context
    In a double-blind placebo-controlled experiment, 100 undergraduate students (50 women) participated in the Yale Interpersonal Stressor (YIPS: Stroud, Tanofsky-Kraff, Wilfley, & Salovey, 2000), a live social rejection paradigm.
    Summary · context
    Prior to the YIPS, participants were randomly assigned to self-administer either intranasal oxytocin (24 IU) or a placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women high in emotion-oriented coping, intranasal oxytocin reduced anxiety in response to a social rejection stressor relative to placebo.

    In plain wordsIn women who cope with stress through emotions, nasal oxytocin reduced anxiety after a social rejection task, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAnxiety response to social rejection stressor in women high in emotion-oriented coping
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    self-administration of intranasal oxytocin reduced anxiety in response to the YIPS relative to the placebo in women high in emotion-oriented coping [b = 4.487, t(91) = 2.09, p < .05]
    2 context sentences
    Summary · context
    In a double-blind placebo-controlled experiment, 100 undergraduate students (50 women) participated in the Yale Interpersonal Stressor (YIPS: Stroud, Tanofsky-Kraff, Wilfley, & Salovey, 2000), a live social rejection paradigm.
    Summary · context
    Prior to the YIPS, participants were randomly assigned to self-administer either intranasal oxytocin (24 IU) or a placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women low in emotion-oriented coping and in men, intranasal oxytocin did not reduce anxiety in response to a social rejection stressor.

    In plain wordsIn women who rarely cope through emotions, and in men, nasal oxytocin did not reduce anxiety after a social rejection task.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnxiety response to social rejection stressor in women low in emotion-oriented coping and in men
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    but not in women low in emotion-oriented coping, or men.
    2 context sentences
    Summary · context
    In a double-blind placebo-controlled experiment, 100 undergraduate students (50 women) participated in the Yale Interpersonal Stressor (YIPS: Stroud, Tanofsky-Kraff, Wilfley, & Salovey, 2000), a live social rejection paradigm.
    Summary · context
    Prior to the YIPS, participants were randomly assigned to self-administer either intranasal oxytocin (24 IU) or a placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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