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Study · In vitro (cells) · 2011

8 results

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.

Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A

Rejuvenation research6 Oct 2011Cited by 6 (Europe PMC)

PMID21978084 (opens in a new tab)DOI10.1089/rej.2011.1172 (opens in a new tab)PepBankPUB-21978084
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In oxidatively stressed cerebellar granule cells, Pinealon restricted reactive oxygen species accumulation in a dose-dependent manner.

    In plain wordsIn cells, Pinealon reduced reactive oxygen species accumulation in stressed cerebellar granule cells in a dose-dependent manner.

    Peptide
    Pinealon
    Outcome
    DecreaseReactive oxygen species accumulation in cerebellar granule cells
    Study

    n: not reported in source

    Oxidatively stressed cerebellar granule cells
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  2. 02LabIn vitro (cells)Mechanism

    In oxidatively stressed neutrophils, Pinealon restricted reactive oxygen species accumulation in a dose-dependent manner.

    In plain wordsIn cells, Pinealon reduced reactive oxygen species accumulation in stressed neutrophils in a dose-dependent manner.

    Peptide
    Pinealon
    Outcome
    DecreaseReactive oxygen species accumulation in neutrophils
    Study

    n: not reported in source

    Oxidatively stressed neutrophils
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  3. 03LabIn vitro (cells)Mechanism

    In oxidatively stressed PC12 cells, Pinealon restricted reactive oxygen species accumulation in a dose-dependent manner.

    In plain wordsIn cells, Pinealon reduced reactive oxygen species accumulation in stressed pheochromocytoma cells in a dose-dependent manner.

    Peptide
    Pinealon
    Outcome
    DecreaseReactive oxygen species accumulation in PC12 cells
    Study

    n: not reported in source

    Oxidatively stressed pheochromocytoma (PC12) cells
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  4. 04LabIn vitro (cells)Efficacy outcome

    In the studied cells, Pinealon decreased necrotic cell death measured by the propidium iodide test.

    In plain wordsIn cells, Pinealon reduced necrotic cell death measured with a dye test.

    Peptide
    Pinealon
    Outcome
    DecreaseNecrotic cell death
    Study

    n: not reported in source

    Cerebellar granule cells, neutrophils, and PC12 cells
    Outcome group
    Neuroprotection · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the same time, pinealon decreases necrotic cell death measured by the propidium iodide test.
    1 context sentence
    Summary · context
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  5. 05LabIn vitro (cells)Mechanism

    In the studied cells, Pinealon protection accompanied a delayed time course of ERK 1/2 activation.

    In plain wordsIn cells, Pinealon protection accompanied delayed activation of ERK proteins.

    Peptide
    Pinealon
    Outcome
    Not applicableERK activation time course
    Study

    n: not reported in source

    Cerebellar granule cells, neutrophils, and PC12 cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective effect of pinealon is accompanied with a delayed time course of ERK 1/2 activation and modification of the cell cycle.
    1 context sentence
    Summary · context
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  6. 06LabIn vitro (cells)Mechanism

    In the studied cells, Pinealon protection accompanied cell cycle modification that continued at higher concentrations.

    In plain wordsIn cells, Pinealon protection accompanied cell cycle changes that continued at higher concentrations.

    Peptide
    Pinealon
    Outcome
    Direction not reportedCell cycle modification
    Study

    n: not reported in source

    Cerebellar granule cells, neutrophils, and PC12 cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas cell cycle modulation continues at higher concentrations of pinealon
    1 context sentence
    Summary · context
    The protective effect of pinealon is accompanied with a delayed time course of ERK 1/2 activation and modification of the cell cycle.
  7. 07LabIn vitro (cells)Mechanism

    In the studied cells, Pinealon restriction of reactive oxygen species accumulation saturated at lower concentrations.

    In plain wordsIn cells, Pinealon's reduction of reactive oxygen species accumulation saturated at lower concentrations.

    Peptide
    Pinealon
    Outcome
    Not applicableConcentration saturation of ROS restriction
    Study

    n: not reported in source

    Cerebellar granule cells, neutrophils, and PC12 cells
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Because restriction of ROS accumulation and cell mortality is saturated at lower concentrations
    1 context sentence
    Summary · context
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
  8. 08LabIn vitro (cells)Mechanism

    In the studied cells, Pinealon restriction of cell mortality saturated at lower concentrations.

    In plain wordsIn cells, Pinealon's reduction of cell death saturated at lower concentrations.

    Peptide
    Pinealon
    Outcome
    Not applicableConcentration saturation of mortality restriction
    Study

    n: not reported in source

    Cerebellar granule cells, neutrophils, and PC12 cells
    Outcome group
    Neuroprotection · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Because restriction of ROS accumulation and cell mortality is saturated at lower concentrations
    1 context sentence
    Summary · context
    The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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