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Study · Animal study (in vivo) · rat · 2012

2 results

The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating.

Feifel D, Shilling PD, Belcher AM

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology1 Oct 2011Cited by 28 (Europe PMC)

PMID21962914 (opens in a new tab)PMCIDPMC4208693 (opens in a new tab)DOI10.1016/j.euroneuro.2011.09.004 (opens in a new tab)PepBankPUB-21962914
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Brown Norway rats with naturally low prepulse inhibition, oxytocin increased prepulse inhibition in a dose-dependent fashion.

    In plain wordsIn rats with naturally low startle filtering, oxytocin improved startle filtering as the dose went up.

    Peptide
    Oxytocin
    Outcome
    IncreasePrepulse inhibition of the startle reflex
    Study

    ratn: not reported in source

    Brown Norway rats (naturally low PPI)
    Comparator
    Saline
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    0.04-1.0 mg/kg · subcutaneousAs given in this study (rat).

    Measurements

    P value
    < 0.01
    PPI increase

    Source sentences

    Summary
    Oxytocin significantly increased PPI (P<0.01) and decreased ASR levels (P<0.01) in BN rats in a dose-dependent fashion.
    2 context sentences
    Summary · context
    In experiment 1, Brown Norway (BN) rats, a rat strain that has naturally low PPI, were given either saline or one of three doses of oxytocin (0.04-1.0 mg/kg, sc).
    Summary · context
    PPI and acoustic startle response (ASR) of rats were tested.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Brown Norway rats, oxytocin decreased acoustic startle response levels in a dose-dependent fashion.

    In plain wordsIn rats, oxytocin lowered the startle response as the dose went up.

    Peptide
    Oxytocin
    Outcome
    DecreaseAcoustic startle response
    Study

    ratn: not reported in source

    Brown Norway rats (naturally low PPI)
    Comparator
    Saline
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    0.04-1.0 mg/kg · subcutaneousAs given in this study (rat).

    Measurements

    P value
    < 0.01
    ASR decrease

    Source sentences

    Summary
    Oxytocin significantly increased PPI (P<0.01) and decreased ASR levels (P<0.01) in BN rats in a dose-dependent fashion.
    2 context sentences
    Summary · context
    In experiment 1, Brown Norway (BN) rats, a rat strain that has naturally low PPI, were given either saline or one of three doses of oxytocin (0.04-1.0 mg/kg, sc).
    Summary · context
    PPI and acoustic startle response (ASR) of rats were tested.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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