[Application thymogen for preoperative preparation of elderly patients with tumor processes in abdominal cavity].

Smirnov VS, Petlenko SV, El'tsin SS

Advances in gerontology = Uspekhi gerontologii1 Jan 2011Cited by 1 (Europe PMC)

PMID21957588PepBankPUB-21957588

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In elderly surgical patients with abdominal or retroperitoneal tumors, preoperative Thymogen helped restore structural and functional cellular immunity parameters.
In plain wordsIn elderly surgical patients with tumors, Thymogen helped restore cellular immunity parameters compared with placebo.
Peptide
Thymogen (oglufanide)
Outcome
Direction not reportedCellular immunity parameters
Study
n: not reported in source
Comparator
Placebo
Outcome group
Immune response · Immune and inflammation
Studied dose
100 mg once a day · intranasal instillation · 7 days before surgeryAs given in this study (human).
Source sentences
Summary
The preoperative use of Thymogen proved to be useful to restore the structural and functional parameters of cellular immunity.
2 context sentences(design, population, supporting numbers)
Summary · context
The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery.
Summary · context
A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out.
Report a problemFND-2195758801
02HumanRandomized controlled trialSafety outcome
In elderly tumor surgery patients, preoperative Thymogen significantly reduced the number of postoperative complications compared with placebo.
In plain wordsIn elderly tumor surgery patients, Thymogen reduced the number of postoperative complications compared with placebo.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseNumber of postoperative complications
Study
n: not reported in source
Comparator
Placebo
Outcome group
Adverse events · Whole body
Studied dose
100 mg once a day · intranasal instillation · 7 days before surgeryAs given in this study (human).
Source sentences
Summary
Immunomodulatory therapy resulted in the significant decrease in the number and range of post-operative complications and the shorting of the postoperative period.
2 context sentences(design, population, supporting numbers)
Summary · context
The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery.
Summary · context
A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out.
Report a problemFND-2195758802
03HumanRandomized controlled trialSafety outcome
In elderly tumor surgery patients, preoperative Thymogen significantly reduced the range of postoperative complications compared with placebo.
In plain wordsIn elderly tumor surgery patients, Thymogen reduced the range of postoperative complications compared with placebo.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseRange of postoperative complications
Study
n: not reported in source
Comparator
Placebo
Outcome group
Adverse events · Whole body
Studied dose
100 mg once a day · intranasal instillation · 7 days before surgeryAs given in this study (human).
Source sentences
Summary
Immunomodulatory therapy resulted in the significant decrease in the number and range of post-operative complications and the shorting of the postoperative period.
2 context sentences(design, population, supporting numbers)
Summary · context
The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery.
Summary · context
A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out.
Report a problemFND-2195758803
04HumanRandomized controlled trialEfficacy outcome
In elderly tumor surgery patients, preoperative Thymogen shortened the postoperative period compared with placebo.
In plain wordsIn elderly tumor surgery patients, Thymogen shortened the postoperative period compared with placebo.
Peptide
Thymogen (oglufanide)
Outcome
DecreasePostoperative period
Study
n: not reported in source
Comparator
Placebo
Outcome group
Intensive care and hospital outcomes · Whole body
Studied dose
100 mg once a day · intranasal instillation · 7 days before surgeryAs given in this study (human).
Source sentences
Summary
Immunomodulatory therapy resulted in the significant decrease in the number and range of post-operative complications and the shorting of the postoperative period.
2 context sentences(design, population, supporting numbers)
Summary · context
The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery.
Summary · context
A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out.
Report a problemFND-2195758804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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