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Study · Animal study (in vivo) · rat · 2012

8 results

Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia.

Vázquez-Roque RA, Ramos B, Tecuatl C, Juárez I, Adame A, de la Cruz F, Zamudio S, Mena R, Rockenstein E, Masliah E, Flores G

Journal of neuroscience research19 Sept 2011Cited by 47 (Europe PMC)

PMID21932359 (opens in a new tab)PMCIDPMC3370993 (opens in a new tab)DOI10.1002/jnr.22753 (opens in a new tab)PepBankPUB-21932359
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl reduced hyperresponsiveness to novel environment-induced locomotion.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced excessive movement in a novel environment.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNovel environment-induced locomotor hyperresponsiveness
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral data show a reduction in the hyperresponsiveness to novel environment- and amphetamine-induced locomotion, with an increase in the total time spent in social interactions and in prepulse inhibition in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl reduced hyperresponsiveness to amphetamine-induced locomotion.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced excessive movement induced by amphetamine.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAmphetamine-induced locomotor hyperresponsiveness
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral data show a reduction in the hyperresponsiveness to novel environment- and amphetamine-induced locomotion, with an increase in the total time spent in social interactions and in prepulse inhibition in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl increased total time spent in social interactions.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl increased time spent in social interactions.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSocial interaction time
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral data show a reduction in the hyperresponsiveness to novel environment- and amphetamine-induced locomotion, with an increase in the total time spent in social interactions and in prepulse inhibition in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl increased prepulse inhibition.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl increased prepulse inhibition.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePrepulse inhibition
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral data show a reduction in the hyperresponsiveness to novel environment- and amphetamine-induced locomotion, with an increase in the total time spent in social interactions and in prepulse inhibition in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl ameliorated dendritic retraction in limbic regions.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced dendritic retraction in limbic brain regions.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDendritic retraction
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, neuropathological analysis of the limbic regions also showed amelioration of dendritic retraction and spine loss in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl ameliorated spine loss in limbic regions.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced dendritic spine loss in limbic brain regions.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSpine loss
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, neuropathological analysis of the limbic regions also showed amelioration of dendritic retraction and spine loss in Cbl-treated nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl ameliorated dendritic pathology in PFC and NAcc.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced dendritic damage in prefrontal cortex and nucleus accumbens.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDendritic pathology in PFC and NAcc
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cbl treatment also ameliorated dendritic pathology and neuronal loss in the PFC and NAcc in nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In nVHL rats, Cbl ameliorated neuronal loss in PFC and NAcc.

    In plain wordsIn rats with neonatal hippocampal lesions, Cbl reduced neuronal loss in prefrontal cortex and nucleus accumbens.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNeuronal loss in PFC and NAcc
    Study

    ratn: not reported in source

    Neonatal ventral hippocampal lesion model of schizophrenia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cbl treatment also ameliorated dendritic pathology and neuronal loss in the PFC and NAcc in nVHL rats.
    1 context sentence
    Summary · context
    This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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