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Study · Randomized controlled trial · n = 65 · 2011

4 results

Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women.

Peichl P, Holzer LA, Maier R, Holzer G

The Journal of bone and joint surgery. American volume1 Sept 2011Cited by 237 (Europe PMC)

PMID21915572 (opens in a new tab)DOI10.2106/jbjs.j.01379 (opens in a new tab)PepBankPUB-21915572
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In elderly osteoporotic women with pelvic fractures, PTH 1‑84 shortened mean healing time to 7.8 weeks versus 12.6 weeks with control.

    In plain wordsIn elderly women with osteoporosis, PTH shortened pelvic fracture healing to 7.8 weeks versus 12.6 weeks with control.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    DecreaseTime to fracture healing
    Study

    n = 65

    Comparator
    Control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 µg once daily · injectionAs given in this study (human).

    Measurements

    Mean time to fracture healing
    7.8 weeks
    PTH 1-84 group
    Mean time to fracture healing
    12.6 weeks
    control group

    Source sentences

    Summary
    The mean time to fracture healing was 7.8 weeks for the treatment group, compared with 12.6 weeks for the control group (p < 0.001).
    2 context sentences
    Summary · context
    The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women.
    Summary · context
    Twenty-one patients received a once-daily injection of 100 µg of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In elderly osteoporotic women, pelvic fracture healing at eight weeks was 100% with PTH 1‑84 versus 9.1% with control.

    In plain wordsIn elderly women with osteoporosis, pelvic fracture healing at eight weeks was 100% with PTH versus 9.1% with control.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseFracture healing at eight weeks
    Study

    n = 65

    Comparator
    Control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 µg once daily · injectionAs given in this study (human).

    Measurements

    Fracture healing rate at eight weeks
    100%
    PTH 1-84 group
    Fracture healing rate at eight weeks
    9.1%
    control group

    Source sentences

    Summary
    At eight weeks, all fractures in the treatment group were healed and four fractures in the control group were healed (healing rate, 100% compared with 9.1%; p < 0.001).
    2 context sentences
    Summary · context
    The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women.
    Summary · context
    Twenty-one patients received a once-daily injection of 100 µg of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In elderly osteoporotic women with pelvic fractures, PTH 1‑84 improved pain scores versus control.

    In plain wordsIn elderly women with osteoporosis and pelvic fractures, PTH improved pain scores versus control.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    Direction not reportedPain visual analog scale
    Study

    n = 65

    Comparator
    Control
    Outcome group
    Pain · Musculoskeletal
    Studied dose
    100 µg once daily · injectionAs given in this study (human).

    Source sentences

    Summary
    Both the visual analog scale score for pain and the result of the Timed "Up and Go" test improved in the study group as compared with the control group (p < 0.001).
    2 context sentences
    Summary · context
    The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women.
    Summary · context
    Twenty-one patients received a once-daily injection of 100 µg of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In elderly osteoporotic women with pelvic fractures, PTH 1‑84 improved Timed Up and Go performance versus control.

    In plain wordsIn elderly women with osteoporosis and pelvic fractures, PTH improved mobility test performance versus control.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    Direction not reportedTimed Up and Go test
    Study

    n = 65

    Comparator
    Control
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    100 µg once daily · injectionAs given in this study (human).

    Source sentences

    Summary
    Both the visual analog scale score for pain and the result of the Timed "Up and Go" test improved in the study group as compared with the control group (p < 0.001).
    2 context sentences
    Summary · context
    The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women.
    Summary · context
    Twenty-one patients received a once-daily injection of 100 µg of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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