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Study · Animal study (in vivo) · mouse and rat · 2011

4 results

ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and β-common receptor knockout mice.

Swartjes M, Morariu A, Niesters M, Brines M, Cerami A, Aarts L, Dahan A

Anesthesiology1 Nov 2011Cited by 42 (Europe PMC)

PMID21873879 (opens in a new tab)DOI10.1097/aln.0b013e31822fcefd (opens in a new tab)PepBankPUB-21873879
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spared nerve injury, ARA290 produced long-term relief of tactile allodynia compared with vehicle, with both treatment schedules.

    In plain wordsIn rats with nerve injury, ARA290 relieved touch-triggered pain for a long time compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTactile allodynia in rats
    Study

    Ratn: not reported in source

    Spared nerve injury model of neuropathic pain
    Comparator
    Vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 μg/kg · intraperitonealAs given in this study (Rat).

    Source sentences

    Summary
    In rats, irrespective of treatment paradigm, ARA290 produced effective, long-term (as long as 15 weeks) relief of tactile and cold allodynia (P < 0.001 vs. vehicle-treated animals).
    2 context sentences
    Summary · context
    The authors assess the effect of a nonhematopoietic erythropoietin analog, ARA290, on tactile and cold allodynia in a model of neuropathic pain (spared nerve injury) in rats and mice lacking the β-common receptor (βcR mice), a component of the receptor complex mediating tissue protection.
    Summary · context
    Twenty-four hours after peripheral nerve injury, rats and mice were injected with ARA290 or vehicle (five 30-μg/kg intraperitoneal injections at 2-day intervals, followed by once/week, n = 8/group).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spared nerve injury, ARA290 produced long-term relief of cold allodynia compared with vehicle, with both treatment schedules.

    In plain wordsIn rats with nerve injury, ARA290 relieved cold-triggered pain for a long time compared with vehicle.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseCold allodynia in rats
    Study

    Ratn: not reported in source

    Spared nerve injury model of neuropathic pain
    Comparator
    Vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 μg/kg · intraperitonealAs given in this study (Rat).

    Source sentences

    Summary
    In rats, irrespective of treatment paradigm, ARA290 produced effective, long-term (as long as 15 weeks) relief of tactile and cold allodynia (P < 0.001 vs. vehicle-treated animals).
    2 context sentences
    Summary · context
    The authors assess the effect of a nonhematopoietic erythropoietin analog, ARA290, on tactile and cold allodynia in a model of neuropathic pain (spared nerve injury) in rats and mice lacking the β-common receptor (βcR mice), a component of the receptor complex mediating tissue protection.
    Summary · context
    Twenty-four hours after peripheral nerve injury, rats and mice were injected with ARA290 or vehicle (five 30-μg/kg intraperitoneal injections at 2-day intervals, followed by once/week, n = 8/group).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with spared nerve injury, ARA290 significantly relieved allodynia.

    In plain wordsIn mice with nerve injury, ARA290 relieved pain triggered by normally harmless touch.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseAllodynia in wild-type mice
    Study

    Mousen: not reported in source

    Spared nerve injury model of neuropathic pain, wild-type mice
    Comparator
    Vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 μg/kg · intraperitonealAs given in this study (Mouse).

    Source sentences

    Summary
    ARA290 was effective in wild-type mice, producing significant relief of allodynia.
    2 context sentences
    Summary · context
    The authors assess the effect of a nonhematopoietic erythropoietin analog, ARA290, on tactile and cold allodynia in a model of neuropathic pain (spared nerve injury) in rats and mice lacking the β-common receptor (βcR mice), a component of the receptor complex mediating tissue protection.
    Summary · context
    Twenty-four hours after peripheral nerve injury, rats and mice were injected with ARA290 or vehicle (five 30-μg/kg intraperitoneal injections at 2-day intervals, followed by once/week, n = 8/group).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice lacking the β-common receptor, ARA290 had no effect on allodynia after spared nerve injury.

    In plain wordsIn mice without the β-common receptor, ARA290 did not relieve pain after nerve injury.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeAllodynia in β-common receptor knockout mice
    Study

    Mousen: not reported in source

    Spared nerve injury model of neuropathic pain, β-common receptor knockout mice
    Comparator
    Vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    30 μg/kg · intraperitonealAs given in this study (Mouse).

    Source sentences

    Summary
    In contrast, in βcR mice no effect of ARA290 was observed.
    2 context sentences
    Summary · context
    The authors assess the effect of a nonhematopoietic erythropoietin analog, ARA290, on tactile and cold allodynia in a model of neuropathic pain (spared nerve injury) in rats and mice lacking the β-common receptor (βcR mice), a component of the receptor complex mediating tissue protection.
    Summary · context
    Twenty-four hours after peripheral nerve injury, rats and mice were injected with ARA290 or vehicle (five 30-μg/kg intraperitoneal injections at 2-day intervals, followed by once/week, n = 8/group).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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