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Study · Animal study (in vivo) · mouse · 2011

2 results

Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.

Enriori PJ, Sinnayah P, Simonds SE, Garcia Rudaz C, Cowley MA

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Aug 2011Cited by 262 (Europe PMC)

PMID21865462 (opens in a new tab)PMCIDPMC3758545 (opens in a new tab)DOI10.1523/jneurosci.2336-11.2011 (opens in a new tab)PepBankPUB-21865462
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral injection of MTII increased interscapular brown adipose tissue temperature, a marker of sympathetic activity.

    In plain wordsIn mice, Melanotan II injection raised the temperature of brown fat, a sign of higher sympathetic nerve activity.

    Peptide
    Melanotan II
    Outcome
    IncreaseInterscapular brown adipose tissue temperature
    Study

    mousen: not reported in source

    Mice with normal body weight
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (mouse).

    Source sentences

    Summary
    Peripheral Melotan II (MTII) injection increased iBAT temperature
    1 context sentence
    Summary · context
    We measured iBAT temperature as a marker of SNA.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In mice, AgRP injected into the dorsomedial hypothalamus blunted the rise in iBAT temperature caused by MTII.

    In plain wordsIn mice, blocking melanocortin receptors in one brain area reduced the brown fat warming caused by Melanotan II.

    Peptide
    Melanotan II
    Outcome
    DecreaseBlockade of MTII-induced iBAT temperature rise by DMH AgRP
    Study

    mousen: not reported in source

    Mice with normal body weight
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight

    Source sentences

    Summary
    but it was blunted by blockade of DMH melanocortin receptors (MC4Rs) by injecting agouti-related peptide (AgRP) directly into the DMH
    1 context sentence
    Summary · context
    We measured iBAT temperature as a marker of SNA.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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