In women, muscle gene expression of IGF-1 splice variant Ec was 40% lower in postmenopausal non-users of hormone therapy than in premenopausal women.
In plain wordsIn women, the body's own IGF-1Ec in muscle was lower after menopause in women not using hormone therapy than in younger women.
- Peptide
- MGF / PEG-MGF
- Outcome
- DecreaseMuscle IGF-1Ec expression, postmenopausal non-users vs premenopausal
- Study
n: not reported in source
- Comparator
- Premenopausal women
- Outcome group
- Aging markers · Musculoskeletal
Measurements
- IGF-1Ec expression difference
- −40%
- postmenopausal non-users vs premenopausal
Source sentences
In muscle, the most notable changes were 28% lower gene expression of IGF-1 splice variant Ea (IGF-1Ea) and 40% lower expression of splice variant Ec (IGF-1Ec) in the postmenopausal non-users than in premenopausal women (p = 0.016 and 0.019, respectively), and 28% higher expression of IGF1-receptor…
1 context sentence(design, population, supporting numbers)
in 30- to 35-year-old (n = 14) women (without hormonal contraceptives) and in 54- to 62-year-old monozygotic female twin pairs discordant for HRT (n = 11 pairs, mean duration of HRT 7.3 ± 3.7 years).
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.