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Study · Animal study (in vivo) · rat · 2011

5 results

Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model.

Idan-Feldman A, Schirer Y, Polyzoidou E, Touloumi O, Lagoudaki R, Grigoriadis NC, Gozes I

Neurobiology of disease27 Jul 2011Cited by 44 (Europe PMC)

PMID21827858 (opens in a new tab)DOI10.1016/j.nbd.2011.06.020 (opens in a new tab)PepBankPUB-21827858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, NAP significantly improved the water maze learning curve.

    In plain wordsIn diabetic rats, NAP improved maze learning compared with vehicle.

    Peptide
    Davunetide
    Outcome
    IncreaseWater maze learning curve
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    Diabetic vehicle group
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. NAP treatment significantly improved both measurements.
    2 context sentences
    Summary · context
    NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model.
    Summary · context
    Intranasal NAP or vehicle was administered daily starting on the day following streptozotocin injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, NAP significantly improved probe memory test performance.

    In plain wordsIn diabetic rats, NAP improved memory test performance compared with vehicle.

    Peptide
    Davunetide
    Outcome
    IncreaseProbe memory test performance
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    Diabetic vehicle group
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. NAP treatment significantly improved both measurements.
    2 context sentences
    Summary · context
    NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model.
    Summary · context
    Intranasal NAP or vehicle was administered daily starting on the day following streptozotocin injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, NAP prevented prefrontal cortex atrophy detected by magnetic resonance imaging.

    In plain wordsIn diabetic rats, NAP prevented prefrontal brain shrinkage compared with vehicle.

    Peptide
    Davunetide
    Outcome
    DecreasePrefrontal cortex atrophy
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    Diabetic vehicle group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    T2 magnetic resonance imaging revealed atrophy in the prefrontal cortex of the diabetes rat group, which was prevented by NAP treatment.
    2 context sentences
    Summary · context
    NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model.
    Summary · context
    Intranasal NAP or vehicle was administered daily starting on the day following streptozotocin injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, NAP protected against major synaptophysin loss.

    In plain wordsIn diabetic rats, NAP protected against loss of synaptophysin compared with vehicle.

    Peptide
    Davunetide
    Outcome
    DecreaseSynaptophysin loss
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    Diabetic vehicle group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical analysis showed that NAP treatment protected against major loss of the synaptic marker synaptophysin and astrocytic apoptosis, resulting from streptozotocin treatment.
    2 context sentences
    Summary · context
    NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model.
    Summary · context
    Intranasal NAP or vehicle was administered daily starting on the day following streptozotocin injection.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, NAP protected against astrocytic apoptosis.

    In plain wordsIn diabetic rats, NAP protected against astrocyte death compared with vehicle.

    Peptide
    Davunetide
    Outcome
    DecreaseAstrocytic apoptosis
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    Diabetic vehicle group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical analysis showed that NAP treatment protected against major loss of the synaptic marker synaptophysin and astrocytic apoptosis, resulting from streptozotocin treatment.
    2 context sentences
    Summary · context
    NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model.
    Summary · context
    Intranasal NAP or vehicle was administered daily starting on the day following streptozotocin injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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