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Study · Not a test of the peptide alone · 2011

4 results

[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].

Kuznik BI, Pateiuk AV, Rusaeva NS, Baranchugova LM, Obydenko VI

Advances in gerontology = Uspekhi gerontologii1 Jan 2011

PMID21809626 (opens in a new tab)PepBankPUB-21809626
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

  1. 01AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken, Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly increased thyroid-stimulating hormone levels and prevented impairments of the thyroid gland.

    In plain wordsIn chickens with the pituitary gland removed, the two tetrapeptides raised thyroid-stimulating hormone levels.

    Peptide
    Epitalon
    Outcome
    IncreaseThyroid-stimulating hormone level
    Study

    chickenn: not reported in source

    Hypophysectomized mature and old birds
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Administration of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly tetrapeptides significantly prevented these impairments by increasing the levels of the thyroid-stimulating hormone (TSH) as well as T3 and T4.
    2 context sentences
    Summary · context
    The aim of the paper was to investigate effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds.
    Summary · context
    Hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 02AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken, Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly increased T3 levels.

    In plain wordsIn chickens with the pituitary gland removed, the two tetrapeptides raised T3 thyroid hormone levels.

    Peptide
    Epitalon
    Outcome
    IncreaseTriiodothyronine (T3) level
    Study

    chickenn: not reported in source

    Hypophysectomized mature and old birds
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Administration of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly tetrapeptides significantly prevented these impairments by increasing the levels of the thyroid-stimulating hormone (TSH) as well as T3 and T4.
    2 context sentences
    Summary · context
    The aim of the paper was to investigate effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds.
    Summary · context
    Hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  3. 03AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken, Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly increased T4 levels.

    In plain wordsIn chickens with the pituitary gland removed, the two tetrapeptides raised T4 thyroid hormone levels.

    Peptide
    Epitalon
    Outcome
    IncreaseThyroxine (T4) level
    Study

    chickenn: not reported in source

    Hypophysectomized mature and old birds
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Administration of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly tetrapeptides significantly prevented these impairments by increasing the levels of the thyroid-stimulating hormone (TSH) as well as T3 and T4.
    2 context sentences
    Summary · context
    The aim of the paper was to investigate effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds.
    Summary · context
    Hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  4. 04AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In hypophysectomized birds given Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly, restoration of thyroid function and morphology was greater in one-year-old chicken than in five-year-old birds.

    In plain wordsIn chickens with the pituitary gland removed, the thyroid recovered more in one-year-old birds than in five-year-old birds after the two tetrapeptides.

    Peptide
    Epitalon
    Outcome
    MixedRestoration of thyroid function and morphology by age
    Study

    chickenn: not reported in source

    Hypophysectomized mature and old birds
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Restoration of the thyroid functions and morphology was registered to be greater in one-year-old chicken as compared to five-year-old ones.
    2 context sentences
    Summary · context
    The aim of the paper was to investigate effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds.
    Summary · context
    Hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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