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Study · Animal study (in vivo) · rat · 2011

7 results

[Mechanism of delta-sleep inducing peptide geroprotective activity].

Bondarenko TI, Maĭboroda EA, Mikhaleva II, Prudchenko IA

Advances in gerontology = Uspekhi gerontologii1 Jan 2011Cited by 2 (Europe PMC)

PMID21809625 (opens in a new tab)PepBankPUB-21809625
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats aged 2 to 24 months, subcutaneous DSIP suppressed lipid peroxidation and prevented the increase of malonic dialdehyde level in tissues and plasma.

    In plain wordsIn rats, DSIP injections suppressed fat oxidation and kept a marker of it, malonic dialdehyde, from rising.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMalonic dialdehyde level in tissues and plasma
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    suppresses lipid peroxidation preventing the increasing of malonic dialdehyde level in rats tissues and plasma
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats of different ages, DSIP stimulated superoxide dismutase activity.

    In plain wordsIn rats, DSIP injections raised the activity of the antioxidant enzyme superoxide dismutase.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats of different ages, DSIP stimulated catalase activity.

    In plain wordsIn rats, DSIP injections raised the activity of the antioxidant enzyme catalase.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCatalase activity
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats of different ages, DSIP stimulated ceruloplasmin activity.

    In plain wordsIn rats, DSIP injections raised the activity of ceruloplasmin, an antioxidant protein.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCeruloplasmin activity
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats of different ages, DSIP stimulated the level of the nonenzymatic antioxidant urea.

    In plain wordsIn rats, DSIP injections raised the level of urea, which the authors count as an antioxidant.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseUrea level as nonenzymatic antioxidant
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed.
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats of different ages, DSIP stimulated the level of the nonenzymatic antioxidant uric acids.

    In plain wordsIn rats, DSIP injections raised the level of uric acid, which the authors count as an antioxidant.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseUric acid level as nonenzymatic antioxidant
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed.
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP increased the volume of the tissue and blood endogenous antioxidant defense system, mainly through the enzymatic antioxidant system, especially in later ontogenesis.

    In plain wordsIn rats, DSIP injections strengthened the body's own antioxidant defenses in tissues and blood, mostly later in life.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTissue and blood endogenous antioxidant defense system
    Study

    ratn: not reported in source

    physiological aging, rats aged 2 to 24 months
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    10 microg/100 g body weight · subcutaneous · 5 consecutive days every monthAs given in this study (rat).

    Source sentences

    Summary
    DSIP increases the volume of tissues and blood endogenous antioxidant defense system mainly by means of enzymatic antioxidant system, especially during later ontogenesis.
    1 context sentence
    Summary · context
    the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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