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Study · Systematic review · n = 505 · 2012

3 results

A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group.

Van IJzendoorn MH, Bakermans-Kranenburg MJ

Psychoneuroendocrinology29 Jul 2011Cited by 243 (Europe PMC)

PMID21802859 (opens in a new tab)DOI10.1016/j.psyneuen.2011.07.008 (opens in a new tab)PepBankPUB-21802859
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In pooled experiments, intranasal oxytocin did not significantly decrease out-group trust.

    In plain wordsIn pooled experiments, nasal oxytocin did not significantly lower trust toward people outside one's own group.

    Peptide
    Oxytocin
    Outcome
    No significant changeOut-group trust
    Study

    n = 505

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    The hypothesis that out-group trust is significantly decreased in the oxytocin condition was not supported.
    1 context sentence
    Summary · context
    Three psychological effects were subjected to meta-analysis: facial emotion recognition (13 effect sizes, N=408), in-group trust (8 effect sizes, N=317), and out-group trust (10 effect sizes; N=505).
  2. 02HumanSystematic reviewEfficacy outcome

    Intranasal oxytocin enhanced the recognition of facial expressions of emotions in pooled experiments.

    In plain wordsIn pooled experiments, nasal oxytocin improved recognition of emotions in faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseFacial emotion recognition
    Study

    n = 408

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    intranasal oxytocin administration enhances the recognition of facial expressions of emotions
    1 context sentence
    Summary · context
    Three psychological effects were subjected to meta-analysis: facial emotion recognition (13 effect sizes, N=408), in-group trust (8 effect sizes, N=317), and out-group trust (10 effect sizes; N=505).
  3. 03HumanSystematic reviewEfficacy outcome

    Intranasal oxytocin elevated the level of in-group trust in pooled experiments.

    In plain wordsIn pooled experiments, nasal oxytocin raised trust toward members of one's own group.

    Peptide
    Oxytocin
    Outcome
    IncreaseIn-group trust
    Study

    n = 317

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    that it elevates the level of in-group trust.
    1 context sentence
    Summary · context
    Three psychological effects were subjected to meta-analysis: facial emotion recognition (13 effect sizes, N=408), in-group trust (8 effect sizes, N=317), and out-group trust (10 effect sizes; N=505).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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