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Study · Animal study (in vivo) · siberian hamster · 2011

2 results

Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis.

Vaughan CH, Shrestha YB, Bartness TJ

Brain research13 Jul 2011Cited by 42 (Europe PMC)

PMID21802070 (opens in a new tab)PMCIDPMC3426614 (opens in a new tab)DOI10.1016/j.brainres.2011.07.003 (opens in a new tab)PepBankPUB-21802070
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Siberian hamsters, microinjection of melanotan II into the subzona incerta significantly increased interscapular brown adipose tissue temperature.

    In plain wordsIn hamsters, melanotan II injected into one brain area raised the temperature of brown fat.

    Peptide
    Melanotan II
    Outcome
    IncreaseInterscapular brown adipose tissue temperature
    Study

    Siberian hamstern: not reported in source

    conscious freely moving hamsters, subzona incerta injection
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    0.025, 0.05 and 0.075 nmol · microinjection into the subzona incertaAs given in this study (Siberian hamster).

    Source sentences

    Summary
    The MC3/4-R agonist, melanotan II [MTII (0.025, 0.05 and 0.075nmol)], and specific MC4-R agonist (cyclo [ß-Ala-His-D-Phe-Arg-Trp-Glu]-NH2; 0.024nmol) both significantly increased IBAT temperature (T(IBAT))

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In Siberian hamsters, immunohistochemistry found neurons or fibers positive for oxytocin in the subzona incerta.

    In plain wordsIn hamsters, the body's own oxytocin was found in nerve cells or fibers of one brain area.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-positive neurons or fibers in the subzona incerta
    Study

    Siberian hamstern: not reported in source

    subzona incerta tissue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    We first performed immunohistochemical characterization of the subZI and found neurons and/or fibers in this area positive for melanin concentrating hormone, oxytocin, arginine vasopressin, agouti-related protein and alpha-melanocyte stimulating hormone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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