Regulated recovery of pulsatile growth hormone secretion from negative feedback: a preclinical investigation.

Veldhuis JD, Bowers CY

American journal of physiology. Regulatory, integrative and comparative physiology27 Jul 2011Cited by 4 (Europe PMC)

PMID21795635PMCIDPMC3197337DOI10.1152/ajpregu.00293.2011PepBankPUB-21795635

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

01HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, recovery of pulsatile GH secretion was greater in women than in men in all four secretagogue regimens.
In plain wordsIn healthy adults, growth hormone release recovered more in women than in men across all four stimulation regimens in a feedback test.
Peptide
GHRP-2
Outcome
Not applicableRecovery of pulsatile GH secretion from negative feedback, women vs men
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Gender determined recovery of pulsatile GH secretion from negative feedback in all four secretagog regimens (0.003 ≤ P ≤ 0.017 for women>men).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563501
02HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, the peptide secretagogue (GHRH, GHRP‑2 or both) controlled the mass of feedback-inhibited GH secretory bursts.
In plain wordsIn healthy adults, the choice of GHRH, GHRP‑2 or both changed the size of growth hormone bursts during feedback.
Peptide
GHRP-2
Outcome
Not applicableMass of feedback-inhibited GH secretory bursts by secretagogue
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Peptidyl secretagog controlled the mass, number, and duration of feedback-inhibited GH secretory bursts (each, P < 0.001)
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563502
03HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, the peptide secretagogue (GHRH, GHRP‑2 or both) controlled the number of feedback-inhibited GH secretory bursts.
In plain wordsIn healthy adults, the choice of GHRH, GHRP‑2 or both changed how many growth hormone bursts occurred during feedback.
Peptide
GHRP-2
Outcome
Not applicableNumber of feedback-inhibited GH secretory bursts by secretagogue
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Peptidyl secretagog controlled the mass, number, and duration of feedback-inhibited GH secretory bursts (each, P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563503
04HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, the peptide secretagogue (GHRH, GHRP‑2 or both) controlled the duration of feedback-inhibited GH secretory bursts.
In plain wordsIn healthy adults, the choice of GHRH, GHRP‑2 or both changed how long growth hormone bursts lasted during feedback.
Peptide
GHRP-2
Outcome
Not applicableDuration of feedback-inhibited GH secretory bursts by secretagogue
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Peptidyl secretagog controlled the mass, number, and duration of feedback-inhibited GH secretory bursts (each, P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563504
05HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, E2 (women) or T (men) administration potentiated pulsatile GH recovery versus placebo.
In plain wordsIn healthy adults, estrogen or testosterone increased pulsatile growth hormone recovery compared with placebo during a feedback test.
Peptide
GHRP-2
Outcome
IncreasePulsatile GH recovery with E2/T
Study
n = 25
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
E(2)/T administration potentiated both pulsatile (P = 0.006) and entropic (P < 0.001) modes of GH recovery.
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563505
06HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, E2 (women) or T (men) administration potentiated entropic GH recovery versus placebo.
In plain wordsIn healthy adults, estrogen or testosterone increased the entropy-based measure of growth hormone recovery compared with placebo.
Peptide
GHRP-2
Outcome
IncreaseEntropic GH recovery with E2/T
Study
n = 25
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
E(2)/T administration potentiated both pulsatile (P = 0.006) and entropic (P < 0.001) modes of GH recovery.
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563506
07HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, IGF-I positively predicted the escape of GH secretory burst number.
In plain wordsIn healthy adults, higher IGF-I was linked to more growth hormone bursts escaping feedback.
Peptide
GHRP-2
Outcome
IncreaseGH secretory burst number predicted by IGF-I
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
IGF-I positively predicted the escape of GH secretory burst number and mode (P = 0.022), whereas body mass index negatively forecast GH secretory burst number and mass (P = 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563507
08HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, IGF-I positively predicted the escape of GH secretory burst mode.
In plain wordsIn healthy adults, higher IGF-I was linked to growth hormone burst mode escaping feedback.
Peptide
GHRP-2
Outcome
IncreaseGH secretory burst mode predicted by IGF-I
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
IGF-I positively predicted the escape of GH secretory burst number and mode (P = 0.022), whereas body mass index negatively forecast GH secretory burst number and mass (P = 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563508
09HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, body mass index negatively forecast GH secretory burst number.
In plain wordsIn healthy adults, higher body mass index was linked to fewer growth hormone bursts during feedback.
Peptide
GHRP-2
Outcome
DecreaseGH secretory burst number predicted by BMI
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
IGF-I positively predicted the escape of GH secretory burst number and mode (P = 0.022), whereas body mass index negatively forecast GH secretory burst number and mass (P = 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563509
10HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In healthy adults in a GH feedback clamp, body mass index negatively forecast GH secretory burst mass.
In plain wordsIn healthy adults, higher body mass index was linked to smaller growth hormone bursts during feedback.
Peptide
GHRP-2
Outcome
DecreaseGH secretory burst mass predicted by BMI
Study
n = 25
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
IGF-I positively predicted the escape of GH secretory burst number and mode (P = 0.022), whereas body mass index negatively forecast GH secretory burst number and mass (P = 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp.
Summary · context
The clamp comprised combined bolus infusion of GH or saline and continuous stimulation by saline GH-releasing hormone (GHRH), GHRP-2, or both peptides after randomly ordered supplementation with placebo (both sexes) vs. E(2) (estrogen; women) and T (testosterone; men).
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2179563510

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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