Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease.

Rockenstein E, Ubhi K, Pham E, Michael S, Doppler E, Novak P, Inglis C, Mante M, Adame A, Alvarez XA, Moessler H, Masliah E

Journal of neuroscience research25 Jul 2011Cited by 13 (Europe PMC)

PMID21793038PMCIDPMC3171597DOI10.1002/jnr.22712PepBankPUB-21793038

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In APP transgenic mice, Cerebrolysin's water-maze memory benefit persisted for 3 months after treatment interruption.
In plain wordsIn mice, Cerebrolysin's memory benefit persisted for 3 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
IncreaseMemory benefit after interruption
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303801
02AnimalAnimal study (in vivo)Efficacy outcome
In APP transgenic mice, Cerebrolysin's water-maze memory benefit dissipated 6 months after treatment termination.
In plain wordsIn mice, Cerebrolysin's memory benefit disappeared 6 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
Direction not reportedMemory benefit at later washout
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303802
03AnimalAnimal study (in vivo)Efficacy outcome
In APP transgenic mice, Cerebrolysin's reduction of neurodegenerative pathology persisted for 3 months after treatment interruption.
In plain wordsIn mice, Cerebrolysin's reduction of nerve degeneration persisted for 3 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
DecreaseNeurodegenerative pathology after interruption
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303803
04AnimalAnimal study (in vivo)Efficacy outcome
In APP transgenic mice, Cerebrolysin's reduction of neurodegenerative pathology dissipated 6 months after treatment termination.
In plain wordsIn mice, Cerebrolysin's reduction of nerve degeneration disappeared 6 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
Direction not reportedNeurodegenerative pathology at later washout
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303804
05AnimalAnimal study (in vivo)Mechanism
In APP transgenic mice, neocortical amyloid plaque load decreased immediately after Cerebrolysin treatment.
In plain wordsIn mice, neocortical amyloid plaque load decreased immediately after Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
DecreaseNeocortical amyloid plaque load immediately after treatment
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303805
06AnimalAnimal study (in vivo)Mechanism
In APP transgenic mice, hippocampal amyloid plaque load decreased immediately after Cerebrolysin treatment.
In plain wordsIn mice, hippocampal amyloid plaque load decreased immediately after Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
DecreaseHippocampal amyloid plaque load immediately after treatment
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303806
07AnimalAnimal study (in vivo)Mechanism
In APP transgenic mice, Cerebrolysin's neocortical amyloid plaque reduction was no longer apparent 3 months after treatment interruption.
In plain wordsIn mice, Cerebrolysin's neocortical plaque reduction disappeared 3 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
Direction not reportedNeocortical amyloid plaque load after interruption
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303807
08AnimalAnimal study (in vivo)Mechanism
In APP transgenic mice, Cerebrolysin's hippocampal amyloid plaque reduction was no longer apparent 3 months after treatment interruption.
In plain wordsIn mice, Cerebrolysin's hippocampal plaque reduction disappeared 3 months after treatment stopped.
Peptide
Cerebrolysin
Outcome
Direction not reportedHippocampal amyloid plaque load after interruption
Study
mousen: not reported in source
APP transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3-month treatment periodAs given in this study (mouse).
Source sentences
Summary
Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice.
Report a problemFND-2179303808

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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