NAP prevents acute cerebral oxidative stress and protects against long-term brain injury and cognitive impairment in a model of neonatal hypoxia-ischemia.

Greggio S, de Paula S, de Oliveira IM, Trindade C, Rosa RM, Henriques JA, DaCosta JC

Neurobiology of disease5 Jul 2011Cited by 22 (Europe PMC)

PMID21757007DOI10.1016/j.nbd.2011.06.018PepBankPUB-21757007

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In neonatal HI rats, NAP prevented acute DNA damage.
In plain wordsIn rats with neonatal brain hypoxia-ischemia, NAP prevented acute DNA damage compared with vehicle.
Peptide
Davunetide
Outcome
DecreaseBrain DNA damage
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
We observed that NAP prevented the acute HI-induced DNA and lipid membrane damage and also recovered the GSH levels in the injured hemisphere of the HI rat pups.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700701
02AnimalAnimal study (in vivo)Efficacy outcome
In neonatal HI rats, NAP prevented acute lipid membrane damage.
In plain wordsIn rats with neonatal brain hypoxia-ischemia, NAP prevented lipid membrane damage compared with vehicle.
Peptide
Davunetide
Outcome
DecreaseLipid membrane damage
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
We observed that NAP prevented the acute HI-induced DNA and lipid membrane damage and also recovered the GSH levels in the injured hemisphere of the HI rat pups.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700702
03AnimalAnimal study (in vivo)Mechanism
In neonatal HI rats, NAP recovered GSH levels in the injured hemisphere.
In plain wordsIn rats with neonatal brain hypoxia-ischemia, NAP restored glutathione in the injured hemisphere compared with vehicle.
Peptide
Davunetide
Outcome
IncreaseReduced glutathione levels
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
We observed that NAP prevented the acute HI-induced DNA and lipid membrane damage and also recovered the GSH levels in the injured hemisphere of the HI rat pups.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700703
04AnimalAnimal study (in vivo)Efficacy outcome
In neonatal HI rats, NAP prevented learning impairment.
In plain wordsIn rats with neonatal brain hypoxia-ischemia, NAP prevented learning impairment compared with vehicle.
Peptide
Davunetide
Outcome
DecreaseLearning impairment
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
Further, NAP was able to prevent impairments in learning and long-term spatial memory and to significantly reduce brain damage up to 7 weeks following the neonatal HI injury.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700704
05AnimalAnimal study (in vivo)Efficacy outcome
In neonatal HI rats, NAP prevented long-term spatial memory impairment.
In plain wordsIn rats with neonatal brain hypoxia-ischemia, NAP prevented long-term spatial memory impairment compared with vehicle.
Peptide
Davunetide
Outcome
DecreaseLong-term spatial memory impairment
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
Further, NAP was able to prevent impairments in learning and long-term spatial memory and to significantly reduce brain damage up to 7 weeks following the neonatal HI injury.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700705
06AnimalAnimal study (in vivo)Efficacy outcome
In neonatal HI rats, NAP significantly reduced brain damage up to 7 weeks after injury.
In plain wordsIn rats, NAP reduced brain damage up to 7 weeks after neonatal hypoxia-ischemia compared with vehicle.
Peptide
Davunetide
Outcome
DecreaseLong-term brain damage
Study
ratn: not reported in source
Neonatal hypoxia-ischemia
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 μg/g · intraperitoneal · Immediately and 24 h after HIAs given in this study (rat).
Source sentences
Summary
Further, NAP was able to prevent impairments in learning and long-term spatial memory and to significantly reduce brain damage up to 7 weeks following the neonatal HI injury.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia.
Summary · context
The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI.
Report a problemFND-2175700706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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