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Study · Animal study (in vivo) · mouse · 2011

3 results

Experimental stimulation of bone healing with teriparatide: histomorphometric and microhardness analysis in a mouse model of closed fracture.

Mognetti B, Marino S, Barberis A, Martin AS, Bala Y, Di Carlo F, Boivin G, Barbos MP

Calcified tissue international24 Jun 2011Cited by 32 (Europe PMC)

PMID21701938 (opens in a new tab)DOI10.1007/s00223-011-9503-3 (opens in a new tab)PepBankPUB-21701938
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with closed tibial fractures, teriparatide accelerated callus mineralization from day 9 onward.

    In plain wordsIn mice with tibial fractures, teriparatide accelerated callus mineralization.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus mineralization
    Study

    mousen: not reported in source

    Closed tibial fracture
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg dailyAs given in this study (mouse).

    Source sentences

    Summary
    Daily administration of 40 μg/kg of teriparatide accelerated callus mineralization from day 9 onward without significant increase of sizes, and at day 15 the microhardness properties of treated callus were similar to those of bone tissue.
    2 context sentences
    Summary · context
    We set up a murine model of closed tibial fracture on which different doses of teriparatide were tested.
    Summary · context
    Teriparatide's effect on callus formation was monitored during the first 4 weeks from fracture.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with closed tibial fractures, teriparatide did not significantly increase callus size.

    In plain wordsIn mice with tibial fractures, teriparatide did not significantly increase callus size.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCallus size
    Study

    mousen: not reported in source

    Closed tibial fracture
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg dailyAs given in this study (mouse).

    Source sentences

    Summary
    Daily administration of 40 μg/kg of teriparatide accelerated callus mineralization from day 9 onward without significant increase of sizes, and at day 15 the microhardness properties of treated callus were similar to those of bone tissue.
    2 context sentences
    Summary · context
    We set up a murine model of closed tibial fracture on which different doses of teriparatide were tested.
    Summary · context
    Teriparatide's effect on callus formation was monitored during the first 4 weeks from fracture.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice receiving teriparatide, callus microhardness at day 15 was similar to bone tissue.

    In plain wordsIn mice receiving teriparatide, callus hardness at day 15 was similar to bone tissue.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCallus microhardness
    Study

    mousen: not reported in source

    Closed tibial fracture
    Comparator
    Bone tissue
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg dailyAs given in this study (mouse).

    Source sentences

    Summary
    Daily administration of 40 μg/kg of teriparatide accelerated callus mineralization from day 9 onward without significant increase of sizes, and at day 15 the microhardness properties of treated callus were similar to those of bone tissue.
    2 context sentences
    Summary · context
    We set up a murine model of closed tibial fracture on which different doses of teriparatide were tested.
    Summary · context
    Teriparatide's effect on callus formation was monitored during the first 4 weeks from fracture.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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