Postweaning, forebrain-specific perturbation of the oxytocin system impairs fear conditioning.

Pagani JH, Lee HJ, Young WS 3rd

Genes, brain, and behavior1 Jul 2011Cited by 25 (Europe PMC)

PMID21668734PMCIDPMC3190044DOI10.1111/j.1601-183x.2011.00709.xPepBankPUB-21668734

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In mice, constitutive loss of the oxytocin receptor or vasopressin 1a receptor left conditioned freezing normal.
In plain wordsIn mice, removing the oxytocin receptor or vasopressin receptor from birth did not change learned fear freezing.
Peptide
Oxytocin
Outcome
No significant changeConditioned freezing in constitutive Oxtr and Avpr1a knockout mice
Study
mousen: not reported in source
Oxtr and Avpr1a knockout mice and forebrain-specific Oxtr loss mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Oxtr(-/-) and Avpr1a(-/-) mice have normal conditioned freezing.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a cued fear conditioning paradigm to examine associative learning in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins postweaning (Oxtr(FB/FB)).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2166873401
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In mice with postweaning forebrain-restricted loss of the oxytocin receptor, freezing during acquisition of cued fear conditioning was reduced.
In plain wordsIn mice lacking the oxytocin receptor in the forebrain from weaning, freezing during fear learning was reduced.
Peptide
Oxytocin
Outcome
DecreaseFreezing during acquisition in forebrain Oxtr loss mice
Study
mousen: not reported in source
Oxtr and Avpr1a knockout mice and forebrain-specific Oxtr loss mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Oxtr(FB/FB) mice have a reduction in freezing behavior during acquisition, as well as during context and cue retention.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a cued fear conditioning paradigm to examine associative learning in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins postweaning (Oxtr(FB/FB)).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2166873402
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In mice with postweaning forebrain-restricted loss of the oxytocin receptor, freezing during context retention was reduced.
In plain wordsIn mice lacking the oxytocin receptor in the forebrain from weaning, freezing when remembering the fear setting was reduced.
Peptide
Oxytocin
Outcome
DecreaseFreezing during context retention in forebrain Oxtr loss mice
Study
mousen: not reported in source
Oxtr and Avpr1a knockout mice and forebrain-specific Oxtr loss mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Oxtr(FB/FB) mice have a reduction in freezing behavior during acquisition, as well as during context and cue retention.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a cued fear conditioning paradigm to examine associative learning in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins postweaning (Oxtr(FB/FB)).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2166873403
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In mice with postweaning forebrain-restricted loss of the oxytocin receptor, freezing during cue retention was reduced.
In plain wordsIn mice lacking the oxytocin receptor in the forebrain from weaning, freezing when remembering the fear cue was reduced.
Peptide
Oxytocin
Outcome
DecreaseFreezing during cue retention in forebrain Oxtr loss mice
Study
mousen: not reported in source
Oxtr and Avpr1a knockout mice and forebrain-specific Oxtr loss mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Oxtr(FB/FB) mice have a reduction in freezing behavior during acquisition, as well as during context and cue retention.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a cued fear conditioning paradigm to examine associative learning in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins postweaning (Oxtr(FB/FB)).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2166873404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

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