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Study · Not a test of the peptide alone · 2011

4 results

Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin.

Szeto A, McCabe PM, Nation DA, Tabak BA, Rossetti MA, McCullough ME, Schneiderman N, Mendez AJ

Psychosomatic medicine2 Jun 2011Cited by 275 (Europe PMC)

PMID21636661 (opens in a new tab)PMCIDPMC3118424 (opens in a new tab)DOI10.1097/psy.0b013e31821df0c2 (opens in a new tab)PepBankPUB-21636661
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyOther

    In human plasma, oxytocin measured by enzyme immunoassay without extraction was more than 100-fold higher than in extracted plasma.

    In plain wordsIn human blood plasma, an oxytocin test without sample extraction gave results more than 100 times higher than with extraction.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin EIA level in unextracted versus extracted plasma
    Study

    n = 39

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    EIA level ratio, unextracted versus extracted
    > 100 fold
    human plasma

    Source sentences

    Summary
    Without extraction, plasma measured by EIA was more than 100-fold higher than in extracted plasma
    1 context sentence
    Summary · context
    Oxytocin was measured in extracted and unextracted human plasma samples (n = 39).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneObservational studyOther

    In human plasma, oxytocin levels in extracted and unextracted samples were minimally correlated.

    In plain wordsIn human blood plasma, oxytocin test results with and without sample extraction hardly matched each other.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation of oxytocin levels in extracted and unextracted plasma
    Study

    n = 39

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Spearman rho
    −0.1
    extracted versus unextracted plasma

    Source sentences

    Summary
    the correlation between oxytocin levels in extracted and unextracted plasma was minimal (Spearman ρ = -0.10, p = .54).
    1 context sentence
    Summary · context
    Oxytocin was measured in extracted and unextracted human plasma samples (n = 39).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneObservational studyOther

    In human plasma, most samples (>90%) were below the level of detection with the radioimmunoassay, with or without extraction.

    In plain wordsIn human blood plasma, one oxytocin test could not detect oxytocin in most samples.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin detection by radioimmunoassay
    Study

    n = 39

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Samples below detection
    > 90%
    RIA

    Source sentences

    Summary
    Using the RIA, most samples (>90%) were below the level of detection with or without extraction.
    1 context sentence
    Summary · context
    Oxytocin was measured in extracted and unextracted human plasma samples (n = 39).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04HumanNot a test of Oxytocin aloneObservational studyOther

    After chromatographic fractionation of human plasma extracts, multiple immunoreactive products besides oxytocin were present, which casts doubt on assay specificity.

    In plain wordsIn human blood plasma, oxytocin tests also picked up other substances, so they may not be specific for oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableImmunospecificity of oxytocin assays after chromatography
    Study

    n = 39

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    After chromatographic fractionation of sample extracts, multiple immunoreactive products were found to be present in addition to oxytocin, which casts doubts on the specificity of the assays.
    2 context sentences
    Summary · context
    Oxytocin and its degradation products were separated by high-performance liquid chromatography and gel filtration chromatography and then assayed by EIA or RIA to identify oxytocin immunoreactive peaks.
    Summary · context
    Oxytocin was measured in extracted and unextracted human plasma samples (n = 39).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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