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Study · Animal study (in vivo) · mouse · 2011

4 results

Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.

Wan J, Shan Y, Shan H, Li G, Wang T, Guan J, Liu X, Chen D, Li W, Lin Z

Frontiers in bioscience (Landmark edition)1 Jun 2011Cited by 12 (Europe PMC)

PMID21622217 (opens in a new tab)DOI10.2741/3894 (opens in a new tab)PepBankPUB-21622217
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cecal ligation and puncture sepsis, thymosin alpha‑1 improved the 72-hour survival rate.

    In plain wordsIn septic mice, thymosin alpha‑1 improved survival at 72 hours.

    Peptide
    Thymosin alpha-1
    Outcome
    Increase72-h survival rate
    Study

    mousen: not reported in source

    Cecal ligation and puncture (CLP) septic mouse model
    Outcome group
    Mortality · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed that the 72-h survival rate was improved, the percentage of CD4(+)CD25(+)Foxp3(+) T lymphocytes decreased and the apoptosis rate of CD4(+)CD25(+) T lymphocytes increased after intervention of Thymosin-alpha1.
    1 context sentence
    Summary · context
    To explore the relationship between Thymosin-alpha1 and Tregs, in this study, we investigated the changing trend in CD4(+)CD25(+)Foxp3(+) T lymphocytes in a CLP septic mouse model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, thymosin alpha‑1 lowered the percentage of CD4+CD25+Foxp3+ regulatory T lymphocytes.

    In plain wordsIn septic mice, thymosin alpha‑1 lowered the share of regulatory T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePercentage of CD4+CD25+Foxp3+ T lymphocytes
    Study

    mousen: not reported in source

    Cecal ligation and puncture (CLP) septic mouse model
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed that the 72-h survival rate was improved, the percentage of CD4(+)CD25(+)Foxp3(+) T lymphocytes decreased and the apoptosis rate of CD4(+)CD25(+) T lymphocytes increased after intervention of Thymosin-alpha1.
    1 context sentence
    Summary · context
    To explore the relationship between Thymosin-alpha1 and Tregs, in this study, we investigated the changing trend in CD4(+)CD25(+)Foxp3(+) T lymphocytes in a CLP septic mouse model.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In septic mice, thymosin alpha‑1 increased the apoptosis rate of CD4+CD25+ T lymphocytes.

    In plain wordsIn septic mice, thymosin alpha‑1 increased the death rate of a group of regulatory T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseApoptosis rate of CD4+CD25+ T lymphocytes
    Study

    mousen: not reported in source

    Cecal ligation and puncture (CLP) septic mouse model
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed that the 72-h survival rate was improved, the percentage of CD4(+)CD25(+)Foxp3(+) T lymphocytes decreased and the apoptosis rate of CD4(+)CD25(+) T lymphocytes increased after intervention of Thymosin-alpha1.
    1 context sentence
    Summary · context
    To explore the relationship between Thymosin-alpha1 and Tregs, in this study, we investigated the changing trend in CD4(+)CD25(+)Foxp3(+) T lymphocytes in a CLP septic mouse model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, thymosin alpha‑1 changed the expression of pro-inflammatory (IL-2, TNF-alpha) and anti-inflammatory (IL-10, TGF-beta) cytokines; the abstract gives no direction per cytokine.

    In plain wordsIn septic mice, thymosin alpha‑1 changed the levels of several inflammatory and anti-inflammatory signals.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedCytokine expression (IL-2, TNF-alpha, IL-10, TGF-beta)
    Study

    mousen: not reported in source

    Cecal ligation and puncture (CLP) septic mouse model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At same time the expression of pro-inflammation cytokines IL-2, TNF-alpha and anti-inflammatory cytokines IL-10 and TGF-beta were regulated.
    1 context sentence
    Summary · context
    To explore the relationship between Thymosin-alpha1 and Tregs, in this study, we investigated the changing trend in CD4(+)CD25(+)Foxp3(+) T lymphocytes in a CLP septic mouse model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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