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Study · In vitro (cells) · mouse · 2011

2 results

Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved.

Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS

Molecular and cellular endocrinology17 May 2011Cited by 34 (Europe PMC)

PMID21616121 (opens in a new tab)DOI10.1016/j.mce.2011.03.010 (opens in a new tab)PepBankPUB-21616121
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In murine 3T3-L1 adipocytes, MT-II stimulated lipolysis through MC5R.

    In plain wordsIn lab tests on mouse fat cells, MT-II triggered fat breakdown through the MC5R receptor.

    Peptide
    Melanotan II
    Outcome
    IncreaseLipolysis stimulated by MT-II via MC5R
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, results obtained in 3T3-L1 cells suggest that lipolysis stimulated by α-MSH, NDP-α-MSH, MT-II, SHU9119 and PG-901 is mediated through MC5R in a cAMP independent manner.
    1 context sentence
    Summary · context
    Using ACTH and α-melanocyte stimulating hormone (α-MSH) generated from proopiomelanocortin (POMC), as well as synthetic MSH analogues to stimulate lipolysis in murine 3T3-L1 adipocytes it is shown that MC2R and MC5R are lipolytic mediators in differentiated 3T3-L1 adipocytes.
  2. 02LabIn vitro (cells)Mechanism

    In murine 3T3-L1 adipocytes, MT-II-stimulated lipolysis occurred in a cAMP-independent manner.

    In plain wordsIn lab tests on mouse fat cells, MT-II triggered fat breakdown without using the cAMP signal.

    Peptide
    Melanotan II
    Outcome
    No significant changecAMP dependence of MT-II-stimulated lipolysis
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, results obtained in 3T3-L1 cells suggest that lipolysis stimulated by α-MSH, NDP-α-MSH, MT-II, SHU9119 and PG-901 is mediated through MC5R in a cAMP independent manner.
    1 context sentence
    Summary · context
    Using ACTH and α-melanocyte stimulating hormone (α-MSH) generated from proopiomelanocortin (POMC), as well as synthetic MSH analogues to stimulate lipolysis in murine 3T3-L1 adipocytes it is shown that MC2R and MC5R are lipolytic mediators in differentiated 3T3-L1 adipocytes.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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