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Study · Animal study (in vivo) · mouse · 2011

3 results

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.

Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N

Regulatory peptides24 May 2011Cited by 5 (Europe PMC)

PMID21609736 (opens in a new tab)DOI10.1016/j.regpep.2011.05.001 (opens in a new tab)PepBankPUB-21609736
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, a single intraperitoneal injection of Selank (100 μg/kg) significantly changed the expression of 34 of 84 inflammation-related genes in the spleen at 6 and 24 h.

    In plain wordsIn mice, one Selank injection changed the activity of 34 of 84 tested inflammation-related genes in the spleen.

    Peptide
    Selank
    Outcome
    MixedExpression of inflammation-related genes in spleen
    Study

    mousen: not reported in source

    spleen
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Measurements

    Genes with significant expression change
    34 genes
    mouse spleen, 84 genes analysed

    Source sentences

    Summary
    We found significant changes in the expression of 34 genes involved in inflammation processes.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, the Bcl6 gene, which has a main role in the immune system, showed significant changes in expression after injection of Selank and of each of two Selank fragments.

    In plain wordsIn mice, Selank changed the activity of the immune-related Bcl6 gene in the spleen.

    Peptide
    Selank
    Outcome
    Direction not reportedBcl6 gene expression in spleen
    Study

    mousen: not reported in source

    spleen
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    The detailed analysis of quantitative data showed that the Bcl6 gene, which plays a main role in the formation and development of the immune system, exhibited significant changes in its expression levels in response to injection of each of the peptides.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, Selank and its fragments changed the expression of Bcl6 target genes and corepressor genes in the spleen.

    In plain wordsIn mice, Selank changed the activity of genes that Bcl6 controls or works with in the spleen.

    Peptide
    Selank
    Outcome
    Direction not reportedExpression of Bcl6 target and corepressor genes
    Study

    mousen: not reported in source

    spleen
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    Also, we observed expression changes for Bcl6 target and corepressor genes under the influence of Selank and its fragments.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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