Skip to content

Study · Animal study (in vivo) · rat · 2011

12 results

A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock.

Patel NS, Nandra KK, Brines M, Collino M, Wong WF, Kapoor A, Benetti E, Goh FY, Fantozzi R, Cerami A, Thiemermann C

Molecular medicine (Cambridge, Mass.)13 May 2011Cited by 29 (Europe PMC)

PMID21607291 (opens in a new tab)PMCIDPMC3188881 (opens in a new tab)DOI10.2119/molmed.2011.00053 (opens in a new tab)PepBankPUB-21607291
Source linkPubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated renal injury and dysfunction.

    In plain wordsIn rats with severe blood loss, pHBSP reduced kidney injury.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseRenal injury/dysfunction after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated hepatic injury and dysfunction.

    In plain wordsIn rats with severe blood loss, pHBSP reduced liver injury.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseHepatic injury/dysfunction after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated pancreas injury and dysfunction.

    In plain wordsIn rats with severe blood loss, pHBSP reduced injury to the pancreas.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreasePancreas injury/dysfunction after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Organ injury · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated neuromuscular injury and dysfunction.

    In plain wordsIn rats with severe blood loss, pHBSP reduced nerve and muscle injury.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseNeuromuscular injury/dysfunction after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Organ injury · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated lung injury and dysfunction.

    In plain wordsIn rats with severe blood loss, pHBSP reduced lung injury.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLung injury/dysfunction after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Organ injury · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe hemorrhagic shock, pHBSP significantly attenuated lung inflammation.

    In plain wordsIn rats with severe blood loss, pHBSP reduced inflammation in the lungs.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLung inflammation after hemorrhagic shock
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pHBSP significantly attenuated (i) organ injury/dysfunction (renal, hepatic, pancreas, neuromuscular, lung) and inflammation (lung)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP increased the phosphorylation of Akt.

    In plain wordsIn rats with severe blood loss, pHBSP increased activation of Akt, a cell-survival protein.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseAkt phosphorylation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the phosphorylation of Akt, glycogen synthase kinase-3β and endothelial nitric oxide synthase, (iii)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP increased the phosphorylation of glycogen synthase kinase-3β.

    In plain wordsIn rats with severe blood loss, pHBSP increased the phosphorylation of glycogen synthase kinase-3β, an enzyme in cell-survival pathways.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseGlycogen synthase kinase-3β phosphorylation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the phosphorylation of Akt, glycogen synthase kinase-3β and endothelial nitric oxide synthase, (iii)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP increased the phosphorylation of endothelial nitric oxide synthase.

    In plain wordsIn rats with severe blood loss, pHBSP increased activation of endothelial nitric oxide synthase, an enzyme of blood vessels.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseEndothelial nitric oxide synthase phosphorylation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the phosphorylation of Akt, glycogen synthase kinase-3β and endothelial nitric oxide synthase, (iii)
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP attenuated the activation of nuclear factor (NF)-κB.

    In plain wordsIn rats with severe blood loss, pHBSP reduced activation of NF-κB, a driver of inflammation.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseNF-κB activation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    attenuated the activation of nuclear factor (NF)-κB
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP attenuated the shock-related increase in p38 phosphorylation.

    In plain wordsIn rats with severe blood loss, pHBSP reduced the rise in p38 activation, a stress-signal protein.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    Decreasep38 phosphorylation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    attenuated the increase in p38 and extracellular signal-regulated kinase (ERK)1/2 phosphorylation
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats with severe hemorrhagic shock, pHBSP attenuated the shock-related increase in ERK1/2 phosphorylation.

    In plain wordsIn rats with severe blood loss, pHBSP reduced the rise in ERK1/2 activation, a stress-signal protein.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseERK1/2 phosphorylation
    Study

    Ratn: not reported in source

    Rat model of severe hemorrhagic shock
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    attenuated the increase in p38 and extracellular signal-regulated kinase (ERK)1/2 phosphorylation
    3 context sentences
    Summary · context
    We investigated whether pyroglutamate helix B-surface peptide (pHBSP), a nonerythropoietic tissue-protective peptide mimicking the 3D structure of erythropoietin, protects against the organ injury/ dysfunction and inflammation in rats subjected to severe hemorrhagic shock (HS).
    Summary · context
    Mean arterial blood pressure was reduced to 35 ± 5 mmHg for 90 min followed by resuscitation with 20 mL/kg Ringer Lactate for 10 min and 50% of the shed blood for 50 min.
    Summary · context
    Rats were euthanized 4 h after the onset of resuscitation. pHBSP was administered 30 min or 60 min into resuscitation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.