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Study · Animal study (in vivo) · japanese white rabbits · 2011

5 results

Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling.

Kudo S, Mizuta H, Takagi K, Hiraki Y

Osteoarthritis and cartilage23 Apr 2011Cited by 32 (Europe PMC)

PMID21571083 (opens in a new tab)DOI10.1016/j.joca.2011.04.007 (opens in a new tab)PepBankPUB-21571083
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, continuous and intermittent PTH(1-84) produced cartilage formation at 4 weeks, whereas saline did not.

    In plain wordsIn rabbits, both PTH schedules produced cartilage at 4 weeks, whereas saline did not.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseCartilage formation at 4 weeks
    Study

    Japanese white rabbitsn: not reported in source

    Full-thickness articular cartilage defects
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articular · 2 weeksAs given in this study (Japanese white rabbits).

    Source sentences

    Summary
    In contrast, cartilage formation occurred at 4 weeks in both the continuous and intermittent PTH-treated defects.
    2 context sentences
    Summary · context
    No evidence of cartilage formation was evident throughout the period of the experiments in injured animals administered saline alone.
    Summary · context
    Cylindrical full-thickness articular cartilage defects of 5mm in diameter were artificially created in the femoral trochlea of male adolescent Japanese white rabbits using a hand-drill. Recombinant human PTH(1-84) was then administered into the joint cavity continuously or intermittently for 2 weeks post-injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, intermittent PTH(1-84) produced regenerated cartilage that resurfaced defects at 8 weeks.

    In plain wordsIn rabbits, intermittent PTH produced cartilage that covered the defects at 8 weeks.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseCartilage resurfacing at 8 weeks
    Study

    Japanese white rabbitsn: not reported in source

    Full-thickness articular cartilage defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articular · 2 weeksAs given in this study (Japanese white rabbits).

    Source sentences

    Summary
    At 8 weeks post-injury, for the intermittently treated defects, the regenerated cartilage successfully resurfaced the defects and the original bone-articular cartilage junction was recovered.
    1 context sentence
    Summary · context
    Cylindrical full-thickness articular cartilage defects of 5mm in diameter were artificially created in the femoral trochlea of male adolescent Japanese white rabbits using a hand-drill. Recombinant human PTH(1-84) was then administered into the joint cavity continuously or intermittently for 2 weeks post-injury.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, the original bone-articular cartilage junction recovered at 8 weeks after intermittent PTH(1-84).

    In plain wordsIn rabbits, the bone-cartilage junction recovered at 8 weeks after intermittent PTH.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseBone-articular cartilage junction recovery
    Study

    Japanese white rabbitsn: not reported in source

    Full-thickness articular cartilage defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articular · 2 weeksAs given in this study (Japanese white rabbits).

    Source sentences

    Summary
    At 8 weeks post-injury, for the intermittently treated defects, the regenerated cartilage successfully resurfaced the defects and the original bone-articular cartilage junction was recovered.
    1 context sentence
    Summary · context
    Cylindrical full-thickness articular cartilage defects of 5mm in diameter were artificially created in the femoral trochlea of male adolescent Japanese white rabbits using a hand-drill. Recombinant human PTH(1-84) was then administered into the joint cavity continuously or intermittently for 2 weeks post-injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, continuously administered PTH(1-84) left defects covered with fibrous or fibrocartilaginous tissue at 8 weeks.

    In plain wordsIn rabbits, continuous PTH left defects covered with fibrous tissue or fibrocartilage at 8 weeks.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    Not applicableDefect tissue after continuous treatment
    Study

    Japanese white rabbitsn: not reported in source

    Full-thickness articular cartilage defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articular · 2 weeksAs given in this study (Japanese white rabbits).

    Source sentences

    Summary
    In contrast, the defects were covered with fibrous or fibrocartilaginous tissues in the continuously administered group.
    2 context sentences
    Summary · context
    At 8 weeks post-injury, for the intermittently treated defects, the regenerated cartilage successfully resurfaced the defects and the original bone-articular cartilage junction was recovered.
    Summary · context
    Cylindrical full-thickness articular cartilage defects of 5mm in diameter were artificially created in the femoral trochlea of male adolescent Japanese white rabbits using a hand-drill. Recombinant human PTH(1-84) was then administered into the joint cavity continuously or intermittently for 2 weeks post-injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, both continuous and intermittent PTH(1-84) significantly increased double-positive mesenchymal cells at 2 weeks after injury.

    In plain wordsIn rabbits, both PTH schedules increased cells positive for PCNA and the PTH/PTHrP receptor at 2 weeks.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreasePCNA and PTH/PTHrP receptor double-positive cells
    Study

    Japanese white rabbitsn: not reported in source

    Full-thickness articular cartilage defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articular · 2 weeksAs given in this study (Japanese white rabbits).

    Source sentences

    Summary
    PCNA and PTH/PTHrP receptor-double positive mesenchymal cells were significantly increased in both the continuous and intermittent PTH-treated defects at 2 weeks post-injury.
    1 context sentence
    Summary · context
    Cylindrical full-thickness articular cartilage defects of 5mm in diameter were artificially created in the femoral trochlea of male adolescent Japanese white rabbits using a hand-drill. Recombinant human PTH(1-84) was then administered into the joint cavity continuously or intermittently for 2 weeks post-injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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