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Study · Randomized controlled trial · n = 27 · 2011

4 results

Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study.

Simeon D, Bartz J, Hamilton H, Crystal S, Braun A, Ketay S, Hollander E

Psychoneuroendocrinology4 May 2011Cited by 101 (Europe PMC)

PMID21546164 (opens in a new tab)DOI10.1016/j.psyneuen.2011.03.013 (opens in a new tab)PepBankPUB-21546164
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with borderline personality disorder and healthy controls, intranasal oxytocin attenuated stress-induced dysphoria after the Trier Social Stress Test, proportionately more in the borderline group (Group x Drug x Time interaction).

    In plain wordsIn adults with borderline personality disorder, oxytocin reduced stress-induced low mood more than placebo, and more than in healthy adults.

    Peptide
    Oxytocin
    Outcome
    DecreaseStress-induced dysphoria (Profile of Mood States)
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    A significant "Group × Drug × Time" interaction effect for dysphoria (p=.04) reflected a proportionately greater attenuation of stress-induced dysphoria in the BPD group after oxytocin administration.
    1 context sentence
    Summary · context
    Fourteen BPD and 13 healthy control (HC) adults received 40 IU intranasal oxytocin or placebo in double-blind randomized order followed by the Trier Social Stress Test.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with borderline personality disorder and healthy controls, the Group x Drug interaction for the stress-induced cortisol surge was only marginal, a tendency toward greater attenuation in the borderline group after oxytocin.

    In plain wordsIn adults with borderline personality disorder, oxytocin showed only a possible, not significant, tendency to lower the stress cortisol rise compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeStress-induced cortisol surge
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additionally, a marginally significant "Group × Drug" interaction effect for cortisol (p=.10) reflected a tendency toward greater attenuation of the stress-induced cortisol surge in the BPD group after oxytocin administration.
    1 context sentence
    Summary · context
    Fourteen BPD and 13 healthy control (HC) adults received 40 IU intranasal oxytocin or placebo in double-blind randomized order followed by the Trier Social Stress Test.
  3. 03HumanRandomized controlled trialMechanism

    In the combined sample, the oxytocin-placebo difference in emotional stress reactivity was predicted by childhood trauma alone and combined with self-esteem.

    In plain wordsIn adults given oxytocin, the oxytocin effect on emotional stress response was linked to childhood trauma, alone and with self-esteem.

    Peptide
    Oxytocin
    Outcome
    Not applicablePredictors of oxytocin-placebo difference in emotional stress reactivity
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    the oxytocin-placebo difference in the emotional stress reactivity was significantly predicted by childhood trauma alone (p=.037) and combined with self-esteem (p=.030)
    1 context sentence
    Summary · context
    Fourteen BPD and 13 healthy control (HC) adults received 40 IU intranasal oxytocin or placebo in double-blind randomized order followed by the Trier Social Stress Test.
  4. 04HumanRandomized controlled trialMechanism

    In the combined sample, the oxytocin-placebo difference in cortisol stress reactivity was predicted only by insecure attachment.

    In plain wordsIn adults given oxytocin, the oxytocin effect on the stress cortisol response was linked only to insecure attachment.

    Peptide
    Oxytocin
    Outcome
    Not applicablePredictors of oxytocin-placebo difference in cortisol stress reactivity
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    whereas the oxytocin-placebo difference in cortisol stress reactivity was predicted only by insecure attachment (p=.013).
    1 context sentence
    Summary · context
    Fourteen BPD and 13 healthy control (HC) adults received 40 IU intranasal oxytocin or placebo in double-blind randomized order followed by the Trier Social Stress Test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

RecruitingPhase 2NCT06364228

Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

University of Nebraskan = 32est. 20 Jun 2026 to est. Jun 2027

Stress

Trial pageClinicalTrials.govUpdated 5 May 2026

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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