Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides.

Phattarataratip E, Olson B, Broffitt B, Qian F, Brogden KA, Drake DR, Levy SM, Banas JA

Molecular oral microbiology31 Jan 2011Cited by 42 (Europe PMC)

PMID21545696PMCIDPMC3092152DOI10.1111/j.2041-1014.2011.00607.xPepBankPUB-21545696

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In vitro, S. mutans strains from children with active caries were more resistant to LL‑37 (listed with salivary HNP-1-2 and HBD-2-3) than strains from caries-free children.
In plain wordsIn lab tests, bacteria from active tooth decay resisted LL‑37 more than bacteria from decay-free mouths.
Peptide
LL-37
Outcome
IncreaseS. mutans resistance to LL-37, caries-active versus caries-free isolates
Study
Streptococcus mutansn: not reported in source
S. mutans isolates from 13-year-old subjects
Comparator
Isolates from caries-free subjects
Outcome group
Infection and antimicrobial activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
We found that S. mutans strains from children with active caries showed greater resistance to salivary HNP-1-2, HBD-2-3 and LL-37 at varying concentrations than those from caries-free subjects.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we hypothesized that unique S. mutans strains, as determined by DNA fingerprinting from sixty 13-year-old subjects with or without experience of caries, would have different susceptibilities to α-defensins-1-3 (HNP-1-3), β-defensins-2-3 (HBD-2-3) and LL-37.
Report a problemFND-2154569601

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02HumanEndogenous levelObservational studyOther
In 13-year-old subjects, salivary levels of LL‑37 and other peptides were highly variable and showed no correlation with caries experience.
In plain wordsIn 13-year-old children, the body's own LL‑37 levels in saliva varied widely and were not linked to tooth decay.
Peptide
LL-37
Outcome
No significant changeSalivary LL-37 level and caries experience
Study
n = 60
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
The salivary levels of these peptides were highly variable among subjects with no correlation to host caries experience.
1 context sentence(design, population, supporting numbers)
Summary · context
The salivary levels of these peptides in subjects were also measured by enzyme-linked immunosorbent assays.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2154569603

Studies that did not test the peptide alone1

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

03LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement
In vitro, combinations of salivary peptides including LL‑37 increased antimicrobial activity against S. mutans either additively or synergistically.
In plain wordsIn lab tests, mixes of natural defence peptides, LL‑37 among them, killed S. mutans more strongly than single peptides, by adding up or working together.
Peptide
LL-37
Outcome
IncreaseAntimicrobial activity of peptide combinations against S. mutans
Study
Streptococcus mutansn: not reported in source
S. mutans isolates
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
In addition, combinations of these peptides increased their antimicrobial activity against S. mutans either additively or synergistically.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we hypothesized that unique S. mutans strains, as determined by DNA fingerprinting from sixty 13-year-old subjects with or without experience of caries, would have different susceptibilities to α-defensins-1-3 (HNP-1-3), β-defensins-2-3 (HBD-2-3) and LL-37.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-2154569602

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:58 UTC
First added · source update from Europe PMC

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