In rats with mild cortical impact injury followed by hemorrhagic hypotension, pHBSP reduced contusion volume at 2 weeks compared with control.
In plain wordsIn rats with brain injury and blood loss, pHBSP led to a smaller injury volume at 2 weeks than control treatment.
- Peptide
- Cibinetide (ARA-290)
- Outcome
- DecreaseContusion volume at 2 weeks post-injury
- Study
Ratn: not reported in source
Rat model of mild cortical impact injury followed by hemorrhagic hypotension- Comparator
- Inactive substance (control)
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 30 μg/kg every 12 h · 3 daysAs given in this study (Rat).
Measurements
- Contusion volume
- 5.9 mm(3)
- pHBSP-treated
- Contusion volume
- 20.8 mm(3)
- control groups
Source sentences
Both treatments reduced contusion volume at 2 weeks post-injury, from 20.8±2.8 mm(3) in the control groups to 7.7±2.0 mm(3) in the EPO-treated group and 5.9±1.5 mm(3) in the pHBSP-treated group (p=0.001).
2 context sentences(design, population, supporting numbers)
Effects on early cerebral hemodynamics and neurological outcome at 2 weeks post-injury were compared in a rat model of mild cortical impact injury (3m/sec, 2.5 mm deformation) followed by 50 min of hemorrhagic hypotension (MAP 40 mm Hg for 50 min).
Rats were randomly assigned to receive 5000 U/kg of EPO, 30 μg/kg of pHBSP, or an inactive substance every 12 h for 3 days, starting at the end of resuscitation from the hemorrhagic hypotension, which was 110 min post-injury.