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Study · Animal study (in vivo) · mouse · 2011

4 results

The chronic administration of cerebrolysin induces plastic changes in the prefrontal cortex and dentate gyrus in aged mice.

Juárez I, González DJ, Mena R, Flores G

Synapse (New York, N.Y.)17 May 2011Cited by 38 (Europe PMC)

PMID21544867 (opens in a new tab)DOI10.1002/syn.20950 (opens in a new tab)PepBankPUB-21544867
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In aged mice, Cerebrolysin significantly increased dendritic spine density in prefrontal cortex pyramidal neurons.

    In plain wordsIn mice, Cerebrolysin increased dendritic spine density in prefrontal cortex neurons.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePFC dendritic spine density
    Study

    mousen: not reported in source

    Aged mice
    Outcome group
    Cytoskeleton and cell structure · Nervous system and cognition
    Studied dose
    5 ml kg(-1) · i.p. · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    In all Cbl-treated mice a significant increase in dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the DG was observed.
    2 context sentences
    Summary · context
    Here we evaluated the effect of this drug on the dendrites of pyramidal neurons of the PFC and CA1 dorsal hippocampus and granule cells from the dentate gyrus (DG) and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice.
    Summary · context
    Cbl (5 ml kg(-1) , i.p.) was administered daily for 60 days to 6-month-old mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged mice, Cerebrolysin significantly increased dendritic spine density in dentate gyrus granule cells.

    In plain wordsIn mice, Cerebrolysin increased dendritic spine density in dentate gyrus cells.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDG dendritic spine density
    Study

    mousen: not reported in source

    Aged mice
    Outcome group
    Cytoskeleton and cell structure · Nervous system and cognition
    Studied dose
    5 ml kg(-1) · i.p. · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    In all Cbl-treated mice a significant increase in dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the DG was observed.
    2 context sentences
    Summary · context
    Here we evaluated the effect of this drug on the dendrites of pyramidal neurons of the PFC and CA1 dorsal hippocampus and granule cells from the dentate gyrus (DG) and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice.
    Summary · context
    Cbl (5 ml kg(-1) , i.p.) was administered daily for 60 days to 6-month-old mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aged mice, Cerebrolysin significantly increased dendritic length in prefrontal cortex pyramidal neurons, close to the soma.

    In plain wordsIn mice, Cerebrolysin increased dendritic length near the cell body in prefrontal cortex neurons.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePFC dendritic length
    Study

    mousen: not reported in source

    Aged mice
    Outcome group
    Cytoskeleton and cell structure · Nervous system and cognition
    Studied dose
    5 ml kg(-1) · i.p. · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    In all Cbl-treated mice a significant increase in dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the DG was observed.
    3 context sentences
    Summary · context
    Interestingly, the enhancement in dendritic length was close to the soma in pyramidal neurons of the PFC whereas in granule neurons of the DG the increase in dendritic length was further from the soma.
    Summary · context
    Here we evaluated the effect of this drug on the dendrites of pyramidal neurons of the PFC and CA1 dorsal hippocampus and granule cells from the dentate gyrus (DG) and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice.
    Summary · context
    Cbl (5 ml kg(-1) , i.p.) was administered daily for 60 days to 6-month-old mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aged mice, Cerebrolysin significantly increased dendritic length in dentate gyrus granule neurons, further from the soma.

    In plain wordsIn mice, Cerebrolysin increased dendritic length further from the cell body in dentate gyrus neurons.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDG dendritic length
    Study

    mousen: not reported in source

    Aged mice
    Outcome group
    Cytoskeleton and cell structure · Nervous system and cognition
    Studied dose
    5 ml kg(-1) · i.p. · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    In all Cbl-treated mice a significant increase in dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the DG was observed.
    3 context sentences
    Summary · context
    Interestingly, the enhancement in dendritic length was close to the soma in pyramidal neurons of the PFC whereas in granule neurons of the DG the increase in dendritic length was further from the soma.
    Summary · context
    Here we evaluated the effect of this drug on the dendrites of pyramidal neurons of the PFC and CA1 dorsal hippocampus and granule cells from the dentate gyrus (DG) and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice.
    Summary · context
    Cbl (5 ml kg(-1) , i.p.) was administered daily for 60 days to 6-month-old mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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