In MCF-7 cells, IGFBP-4 sense transfection did not change responsiveness to Des(1‑3)IGF-I compared with control and antisense cells.
In plain wordsIn cells, responsiveness to Des(1‑3)IGF-I was equal across control, IGFBP-4 sense, and antisense groups.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeResponse to Des(1-3)IGF-I
- Study
humann: not reported in source
MCF-7 cells- Comparator
- Vector-transfected and antisense IGFBP-4 cells
- Outcome group
- Tumor growth · Cancer
Source sentences
Equal response to Des (1-3) IGF-I (an IGF-I analogue with reduced affinity for IGF binding proteins) was observed for C13, S11 and AS4 cells, suggesting that loss of responsiveness to IGFs by S11 cells is a consequence of IGFBP-4 expression.
1 context sentence(design, population, supporting numbers)
Sense and antisense complementary DMA of human IGFBP-4 were ligated into a mammalian expression vector and transfected into MCF-7 cells in order to investigate the role of IGFBP-4 on breast cancer cell proliferation in vitro and in vivo.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).